STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADK82112.1Homocitrate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891:IPR002034; KEGG: cts:Ctha_1654 homocitrate synthase; PFAM: pyruvate carboxyltransferase; PRIAM: Homocitrate synthase; SPTR: Homocitrate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa)    
Predicted Functional Partners:
ADK83252.1
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 0.979
ADK81410.1
acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.956
ADK79763.1
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR002880:IPR019752:IPR019456:IPR001450:IPR 011766:IPR017900:IPR017896:IPR011895; KEGG: tde:TDE0665 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin iron-sulfur binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Pyruvate ferredoxin/flavodoxin oxi [...]
  
 
 0.945
ADK80735.1
2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR000891:IPR013709:IPR002034; KEGG: tnp:Tnap_0332 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: 2-isopropylmal [...]
 
  
 
0.929
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.925
ADK83059.1
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR018211:IPR015590:IPR001670:IPR012079; KEGG: tel:tlr0227 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; SPTR: Iron-containing alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.920
ADK79734.1
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: ote:Oter_2845 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; biotin/lipoyl attachment domain-containing protein; SPTR: Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); [...]
     
 0.911
ADK79754.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: adg:Adeg_1385 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: 2-oxoglutarate oxidoreductase alpha subunit; PFAM: domain.
  
 
 0.909
ADK79755.1
Thiamine pyrophosphate protein domain protein TPP-binding protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: cbl:CLK_2865 putative 2-oxoacid:acceptor oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Putative 2-oxoacid:acceptor oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
   
 
 0.909
ADK80639.1
Phosphate acetyltransferase; COGs: COG0280 Phosphotransacetylase; InterPro IPR002505:IPR004614:IPR012147; KEGG: hor:Hore_10200 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; PRIAM: Phosphate acetyltransferase; SPTR: Phosphate acetyltransferase; TIGRFAM: phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase.
     
 0.904
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
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