STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADK82607.1Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (245 aa)    
Predicted Functional Partners:
ADK82606.1
COGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184:IPR001150:IPR019777:IPR005949; KEGG: cyc:PCC7424_2838 formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Formate acetyltransferase; TIGRFAM: formate acetyltransferase; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; formate acetyltransferase 1.
  
 0.992
ADK83247.1
COGs: COG1882 Pyruvate-formate lyase; InterPro IPR004184:IPR001150:IPR010098; KEGG: pca:Pcar_1397 glycerol dehydratase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Glycerol dehydratase; TIGRFAM: pyruvate formate-lyase; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: formate acetyltransferase 1; pyruvate formate-lyase.
  
 0.902
ADK79379.1
COGs: COG1882 Pyruvate-formate lyase; InterPro IPR010098:IPR004184:IPR001150; KEGG: str:Sterm_1074 pyruvate formate-lyase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical; PRIAM: Formate C-acetyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: pyruvate formate-lyase; PFAM: Glycine radical; Pyruvate formate lyase; TIGRFAM: pyruvate formate-lyase.
  
 0.901
ADK83059.1
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR018211:IPR015590:IPR001670:IPR012079; KEGG: tel:tlr0227 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; SPTR: Iron-containing alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
  
 0.627
ADK82605.1
Transcriptional regulator, LysR family; COGs: COG0583 Transcriptional regulator; InterPro IPR000847; KEGG: dal:Dalk_5021 chromosome replication initiation inhibitor protein; PFAM: regulatory protein LysR; SPTR: Transcriptional regulator, ArgP, LysR family; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: transcriptional regulator, ArgP family.
       0.516
ADK82608.1
Hypothetical protein; KEGG: cau:Caur_1651 GAF domain-containing protein; SPTR: GAF domain protein.
       0.433
ADK79763.1
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR002880:IPR019752:IPR019456:IPR001450:IPR 011766:IPR017900:IPR017896:IPR011895; KEGG: tde:TDE0665 pyruvate ferredoxin/flavodoxin oxidoreductase family protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin iron-sulfur binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; SPTR: Pyruvate ferredoxin/flavodoxin oxi [...]
     
 0.432
Your Current Organism:
Sediminispirochaeta smaragdinae
NCBI taxonomy Id: 573413
Other names: S. smaragdinae DSM 11293, Sediminispirochaeta smaragdinae DSM 11293, Spirochaeta smaragdinae DSM 11293
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.