Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Fusion
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SI65_05575
C2H2-type domain-containing protein. (486 aa)
Predicted Functional Partners:
SI65_02802
Pre-mRNA-splicing factor prp46.
0.748
SI65_01094
BPL/LPL catalytic domain-containing protein.
0.474
Your Current Organism:
Aspergillus cristatus
NCBI taxonomy Id: 573508 Other names: A. cristatus, ATCC 16468, Aspergillus cristatellus, CBS 123.53, Eurotium cristatum, IMI 172278, IMI 172280, NRRL 4222