Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADL13508.1Phospholipase D/Transphosphatidylase; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: fph:Fphi_1735 cardiolipin synthetase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; SPTR: C1UU52 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase. (368 aa)    
Predicted Functional Partners:
ADL13028.1
COGs: COG1267 Phosphatidylglycerophosphatase A and related protein; InterPro IPR007686; KEGG: sul:SYO3AOP1_0645 phosphatidylglycerophosphatase A; PFAM: phosphatidylglycerophosphatase A; SPTR: B2V8K8 Phosphatidylglycerophosphatase A; PFAM: Phosphatidylglycerophosphatase A.
     
 0.911
ADL12126.1
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004797:IPR004477; KEGG: hor:Hore_12920 DNA internalization-related competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: B8CXM3 DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
 
 
 
 0.624
ADL12182.1
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR012999:IPR003016:IPR013027:IPR000815:IPR 004099:IPR000089:IPR016156:IPR011053:IPR006258; KEGG: hor:Hore_21030 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; biotin/lipoyl attachment domain-containing protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: B8CZZ6 Dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleoti [...]
  
 
 0.555
ADL12273.1
KEGG: acl:ACL_1055 hypothetical protein; SPTR: A9NH35 Putative uncharacterized protein.
  
     0.544
ADL13685.1
Outer membrane chaperone Skp (OmpH); InterPro IPR005632; KEGG: hor:Hore_17660 hypothetical protein; PFAM: outer membrane chaperone Skp (OmpH); SPTR: B8CYZ6 Putative uncharacterized protein; PFAM: Outer membrane protein (OmpH-like).
  
    0.516
ADL13688.1
Protein of unknown function DUF490; COGs: COG2911 conserved hypothetical protein; InterPro IPR007452; KEGG: hor:Hore_17710 hypothetical protein; PFAM: protein of unknown function DUF490; SPTR: B8CZ01 Uncharacterized protein conserved in bacteria; PFAM: Family of unknown function (DUF490).
  
    0.514
mprF
Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
 
  
 0.493
ADL12256.1
single-stranded-DNA-specific exonuclease RecJ; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterProIPR001667:IPR003156:IPR014905:IPR011545:IPR 001650:IPR014021:IPR014001:IPR004610; KEGG: cdf:CD2746 putative single-stranded-DNA-specific exonuclease; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; HIRAN; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Q183I1 Putative single-stranded-DNA-specific exonuclease; TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: DHHA1 domain; DH [...]
 
  
 0.480
ADL13001.1
InterPro IPR017946:IPR004129; KEGG: tde:TDE0799 glycerophosphoryl diester phosphodiesterase, putative; PFAM: glycerophosphoryl diester phosphodiesterase; SPTR: C7GAV3 Glycerophosphoryl diester phosphodiesterase family protein; PFAM: Glycerophosphoryl diester phosphodiesterase family.
     
 0.476
ADL12753.1
KEGG: trq:TRQ2_0374 hypothetical protein; SPTR: C7I833 Putative uncharacterized protein.
 
   
 0.472
Your Current Organism:
Acetohalobium arabaticum
NCBI taxonomy Id: 574087
Other names: A. arabaticum DSM 5501, Acetohalobium arabaticum DSM 5501, Acetohalobium arabaticum str. DSM 5501, Acetohalobium arabaticum strain DSM 5501
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.