STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACIS_00658Hypothetical protein; Possible subunit of a heme lyase. (141 aa)    
Predicted Functional Partners:
ccmF
Cytochrome c-type biogenesis protein.
 
  
 0.891
ACIS_01120
Putative reductase; Contains conserved domain cd03010: TlpA-like family, DsbE.
 
  
 0.863
ccmE
Cytochrome c-type biogenesis protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
  
 0.849
ccmC
Putative ABC-type transport system protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
   
 0.802
ACIS_00657
Hypothetical protein.
       0.602
fdx
Ferredoxin.
       0.547
ccmB
Cytochrome c-type biogenesis protein/heme exporter protein.
 
   
 0.490
ccmA
Cytochrome c biogenesis protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
   
 0.462
ACIS_00653
Contains conserved domain COG0316: Fe-S cluster assembly scaffold protein; Belongs to the HesB/IscA family.
       0.413
hscB
Co-chaperone protein HscB.
       0.413
Your Current Organism:
Anaplasma centrale
NCBI taxonomy Id: 574556
Other names: A. centrale str. Israel, Anaplasma centrale str. Israel, Anaplasma centrale strain Israel, Anaplasma marginale subsp. centrale str. Israel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.