STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
I0YX50_COCSCDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (549 aa)    
Predicted Functional Partners:
I0YWK3_COCSC
DNA ligase.
  
 0.992
I0YWL4_COCSC
HIT-like protein.
   
 0.827
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.757
I0Z5U6_COCSC
DNA ligase.
  
 0.681
I0YW72_COCSC
ATP-dependent DNA helicase ii.
    
 0.646
I0YKK5_COCSC
DNA ligase.
  
 0.630
I0YTK5_COCSC
Ku domain-containing protein.
     
 0.603
I0YU24_COCSC
PIN domain-like protein.
   
 0.594
I0Z1S5_COCSC
PNK3P-domain-containing protein.
    
 0.553
I0Z997_COCSC
P-loop containing nucleoside triphosphate hydrolase protein.
    
 0.553
Your Current Organism:
Coccomyxa subellipsoidea
NCBI taxonomy Id: 574566
Other names: C. subellipsoidea C-169, Chlorella vulgaris C-169, Coccomyxa sp. C-169, Coccomyxa subellipsoidea C-169
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