I0Z2G3_COCSC protein (Coccomyxa subellipsoidea)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

I0Z2G3_COCSC

Spc7 domain-containing protein. (1382 aa)

Predicted Functional Partners:

I0YL80_COCSC

Uncharacterized protein.

0.853

I0YL85_COCSC

Uncharacterized protein.

0.596

I0YN69_COCSC

SCP domain-containing protein.

0.596

Your Current Organism:

Coccomyxa subellipsoidea

NCBI taxonomy Id: 574566
Other names: C. subellipsoidea C-169, Chlorella vulgaris C-169, Coccomyxa sp. C-169, Coccomyxa subellipsoidea C-169

Basic Settings

Network type:

full STRING network

( the edges indicate both functional and physical protein associations )

physical subnetwork

( the edges indicate that the proteins are part of a physical complex )

meaning of network edges:

evidence

( line color indicates the type of interaction evidence )

confidence

( line thickness indicates the strength of data support )

active interaction sources:

Textmining

Experiments

Databases

Co‑expression

Neighborhood

Gene Fusion

Co‑occurrence

minimum required interaction score:

confidence:

max number of interactors to show:

1st shell:

max interactors:

2nd shell:

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Advanced Settings

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( network is a scalable vector graphic [SVG]; interactive )

network display options:

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Export your current network:

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I0YL80_COCSC	I0Z2G3_COCSC	I0YL80	I0Z2G3	Uncharacterized protein.	Spc7 domain-containing protein.	0.853
I0YL85_COCSC	I0Z2G3_COCSC	I0YL85	I0Z2G3	Uncharacterized protein.	Spc7 domain-containing protein.	0.596
I0YN69_COCSC	I0Z2G3_COCSC	I0YN69	I0Z2G3	SCP domain-containing protein.	Spc7 domain-containing protein.	0.596
I0Z2G3_COCSC	I0YL80_COCSC	I0Z2G3	I0YL80	Spc7 domain-containing protein.	Uncharacterized protein.	0.853
I0Z2G3_COCSC	I0YL85_COCSC	I0Z2G3	I0YL85	Spc7 domain-containing protein.	Uncharacterized protein.	0.596
I0Z2G3_COCSC	I0YN69_COCSC	I0Z2G3	I0YN69	Spc7 domain-containing protein.	SCP domain-containing protein.	0.596

[ The below analysis is limited to the network nodes included in the specified statistical background ]

Network Stats

number of nodes:

number of edges:

average node degree:

1.6

avg. local clustering coefficient:

0.8

expected number of edges:

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005576

Extracellular region

3 of 40

1.38

0.91

0.0168

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1857

Ell wall binding domain 2 (CWB2)

4 of 11

2.07

2.77

1.56e-05

CL:1859

Ell wall binding domain 2 (CWB2)

2 of 6

2.03

1.26

0.0100

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031012

Extracellular matrix

3 of 17

1.76

1.42

0.0032

GOCC:0005576

Extracellular region

4 of 61

1.33

1.11

0.0032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04122

Ell wall binding domain 2 (CWB2)

4 of 33

1.59

1.63

0.00049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007253

Putative cell wall binding repeat 2

4 of 33

1.59

1.46

0.0014

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Clustering Options

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( legacy version of k-means algorithm )

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