node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFV20999.1 | SFV21128.1 | SAMN04487966_102129 | SAMN04487966_102196 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Branched-chain amino acid aminotransferase. | 0.406 |
SFV20999.1 | SFV21138.1 | SAMN04487966_102129 | SAMN04487966_102201 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Acetolactate synthase, small subunit. | 0.893 |
SFV20999.1 | ilvC | SAMN04487966_102129 | SAMN04487966_102200 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.416 |
SFV20999.1 | ilvD | SAMN04487966_102129 | SAMN04487966_102203 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.412 |
SFV20999.1 | ldh | SAMN04487966_102129 | SAMN04487966_10959 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.909 |
SFV20999.1 | leuA | SAMN04487966_102129 | SAMN04487966_10437 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.866 |
SFV20999.1 | leuC | SAMN04487966_102129 | SAMN04487966_102183 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.859 |
SFV21128.1 | SFV20999.1 | SAMN04487966_102196 | SAMN04487966_102129 | Branched-chain amino acid aminotransferase. | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.406 |
SFV21128.1 | SFV21138.1 | SAMN04487966_102196 | SAMN04487966_102201 | Branched-chain amino acid aminotransferase. | Acetolactate synthase, small subunit. | 0.766 |
SFV21128.1 | SFV22964.1 | SAMN04487966_102196 | SAMN04487966_105161 | Branched-chain amino acid aminotransferase. | Glutamate synthase (NADPH/NADH) large chain. | 0.458 |
SFV21128.1 | ilvC | SAMN04487966_102196 | SAMN04487966_102200 | Branched-chain amino acid aminotransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.852 |
SFV21128.1 | ilvD | SAMN04487966_102196 | SAMN04487966_102203 | Branched-chain amino acid aminotransferase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.995 |
SFV21128.1 | ldh | SAMN04487966_102196 | SAMN04487966_10959 | Branched-chain amino acid aminotransferase. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.862 |
SFV21128.1 | leuA | SAMN04487966_102196 | SAMN04487966_10437 | Branched-chain amino acid aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.984 |
SFV21128.1 | leuB | SAMN04487966_102196 | SAMN04487966_102197 | Branched-chain amino acid aminotransferase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.818 |
SFV21128.1 | leuC | SAMN04487966_102196 | SAMN04487966_102183 | Branched-chain amino acid aminotransferase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.753 |
SFV21128.1 | leuD | SAMN04487966_102196 | SAMN04487966_102182 | Branched-chain amino acid aminotransferase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.484 |
SFV21138.1 | SFV20999.1 | SAMN04487966_102201 | SAMN04487966_102129 | Acetolactate synthase, small subunit. | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.893 |
SFV21138.1 | SFV21128.1 | SAMN04487966_102201 | SAMN04487966_102196 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.766 |
SFV21138.1 | SFV22964.1 | SAMN04487966_102201 | SAMN04487966_105161 | Acetolactate synthase, small subunit. | Glutamate synthase (NADPH/NADH) large chain. | 0.825 |