STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0083PfkB domain protein; COGs: COG0524 Sugar kinase ribokinase family; InterPro IPR002139: IPR011611; KEGG: syx:SynWH7803_0167 ribokinase family sugar kinase; PFAM: PfkB domain protein; SPTR: Putative sugar kinase; PFAM: pfkB family carbohydrate kinase. (327 aa)    
Predicted Functional Partners:
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006062: IPR006063; KEGG: msl:Msil_2551 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phospho [...]
  
    0.609
Isop_2501
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
    
 
 0.571
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.567
Isop_3302
Monosaccharide ABC transporter membrane protein, CUT2 family; COGs: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems permease components; InterPro IPR001851; KEGG: plm:Plim_0780 inner-membrane translocator; PFAM: inner-membrane translocator; SPTR: Sugar ABC transporter permease protein; PFAM: Branched-chain amino acid transport system / permease component.
 
  
 0.561
ftsH
Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
       0.543
Isop_0252
RbsD or FucU transport; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
 
  
 0.519
rbsA
Monosaccharide ABC transporter ATP-binding protein, CUT2 family; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
 
  
 0.513
Isop_3304
Monosaccharide ABC transporter substrate-binding protein, CUT2 family; COGs: COG1879 ABC-type sugar transport system periplasmic component; KEGG: plm:Plim_0778 ribose ABC transporter periplasmic-binding protein; SPTR: ABC transporter sugar-binding protein.
 
  
 0.474
Isop_1420
InterPro IPR006148; KEGG: plm:Plim_2730 glucosamine/galactosamine-6-phosphate isomerase; PFAM: glucosamine/galactosamine-6-phosphate isomerase; SPTR: Glucosamine-6-phosphate isomerase, putative; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.
 
  
 0.469
Isop_2135
Xylose isomerase domain-containing protein TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307; KEGG: sit:TM1040_3346 xylose isomerase-like TIM barrel; PFAM: Xylose isomerase domain-containing protein TIM barrel; SPTR: Myo-inositol catabolism protein; PFAM: Xylose isomerase-like TIM barrel.
 
    0.466
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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