STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (385 aa)    
Predicted Functional Partners:
Isop_0351
COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: rca:Rcas_2758 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; PFAM: Cobalamin-independent synthase, Catalytic domain.
  
 0.970
Isop_0668
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.952
Isop_0581
Cys/Met metabolism pyridoxal-phosphate-dependent protein; COGs: COG0626 Cystathionine beta-lyase/cystathionine gamma-synthase; InterPro IPR000277; KEGG: rsh:Rsph17029_1561 cystathionine gamma-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; SPTR: Cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme.
   
 0.928
Isop_1131
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: ade:Adeh_1778 homocysteine S-methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: Homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase.
  
 
 0.916
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.866
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.790
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.717
Isop_3311
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR004620: IPR003171; KEGG: pca:Pcar_1732 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; PRIAM: Methylenetetrahydrofolate reductase (NAD(P)H); SPTR: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.710
Isop_2061
GTP-binding protein YchF; COGs: COG0012 GTPase probable translation factor; InterPro IPR013029: IPR004396: IPR006073; KEGG: mta:Moth_2477 GTP-dependent nucleic acid-binding protein EngD; PFAM: protein of unknown function DUF933; SPTR: Putative uncharacterized protein; TIGRFAM: GTP-binding protein YchF; PFAM: GTPase of unknown function; Protein of unknown function (DUF933); TIGRFAM: GTP-binding protein YchF.
 
 
 0.683
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.669
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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