STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
Isop_0152alpha-L-glutamate ligase, RimK family; COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR011761: IPR004666: IPR013651; KEGG: psl:Psta_3185 alpha-L-glutamate ligase, RimK family; PFAM: RimK domain protein ATP-grasp; SPTR: Probable ribosomal protein S6 modification protein; TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: RimK-like ATP-grasp domain; TIGRFAM: alpha-L-glutamate ligases, RimK family; Belongs to the RimK family. (315 aa)    
Predicted Functional Partners:
Isop_0151
COGs: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; InterPro IPR002736; KEGG: psl:Psta_4265 triphosphoribosyl-dephospho-CoA protein; PFAM: triphosphoribosyl-dephospho-CoA protein; SPTR: Triphosphoribosyl-dephospho-CoA protein; PFAM: ATP:dephospho-CoA triphosphoribosyl transferase.
 
     0.863
Isop_0153
COGs: COG0515 Serine/threonine protein kinase; InterProIPR000719: IPR017441: IPR008271: IPR017442: IPR 020635: IPR002290; KEGG: psl:Psta_1107 serine/threonine protein kinase; PFAM: Serine/threonine-protein kinase-like domain; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, catalytic domain; SPTR: Serine/threonine protein kinase; PFAM: Protein kinase domain.
       0.773
Isop_3055
COGs: COG1907 sugar kinase; InterPro IPR004422; KEGG: xau:Xaut_3535 beta-ribofuranosylaminobenzene 5'-phosphate synthase; SPTR: Beta-ribofuranosylaminobenzene 5'-phosphate synthase family; TIGRFAM: beta-ribofuranosylaminobenzene 5'-phosphate synthase family; PFAM: GHMP kinases C terminal; TIGRFAM: beta-RFAP synthase.
 
     0.667
Isop_1012
InterPro IPR015259; KEGG: psl:Psta_2659 methylenetetrahydrofolate dehydrogenase (NADP(+)); PFAM: Methylene-tetrahydromethanopterin dehydrogenase; PRIAM: Methylenetetrahydrofolate dehydrogenase (NADP(+)); SPTR: Methylenetetrahydrofolate dehydrogenase (NADP(+)); PFAM: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal.
 
     0.655
Isop_2542
Dihydropteroate synthase DHPS; InterPro IPR000489; KEGG: psl:Psta_2634 dihydropteroate synthase DhpS; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase DHPS; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase-related protein.
  
     0.645
Isop_2074
Protein of unknown function DUF201; COGs: COG2232 ATP-dependent carboligase related to biotin carboxylase; InterPro IPR003806: IPR011761; KEGG: met:M446_5779 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: Putative uncharacterized protein; PFAM: ATP-grasp domain.
 
     0.641
Isop_2543
Protein of unknown function DUF447; COGs: COG2457 conserved hypothetical protein; InterPro IPR007386; KEGG: psl:Psta_2631 protein of unknown function DUF447; PFAM: protein of unknown function DUF447; SPTR: Conserved protein; PFAM: Protein of unknown function (DUF447).
  
     0.636
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
     0.620
ffsA
Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
     0.603
Isop_0524
COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR013108: IPR012027; KEGG: psl:Psta_0063 formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; SPTR: Formylmethanofuran dehydrogenase subunit A; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A.
 
     0.603
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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