STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
Isop_0231ATP:cob(I)alamin adenosyltransferase; COGs: COG2096 conserved hypothetical protein; InterPro IPR017858: IPR002779; KEGG: rmr:Rmar_1592 ATP/cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; PRIAM: Cob(I)yrinic acid a,c-diamide adenosyltransferase; SPTR: ATP/cobalamin adenosyltransferase; TIGRFAM: ATP/cobalamin adenosyltransferase; PFAM: Cobalamin adenosyltransferase; TIGRFAM: ATP:cob(I)alamin adenosyltransferase. (185 aa)    
Predicted Functional Partners:
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
    
 0.920
Isop_3350
CobB/CobQ domain protein glutamine amidotransferase; COGs: COG1797 Cobyrinic acid a c-diamide synthase; InterPro IPR017929: IPR011698; KEGG: psl:Psta_3042 CobB/CobQ domain protein glutamine amidotransferase; PFAM: CobB/CobQ domain protein glutamine amidotransferase; SPTR: CobB/CobQ domain protein glutamine amidotransferase; PFAM: CobB/CobQ-like glutamine amidotransferase domain.
    
 0.913
Isop_3300
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR003043: IPR006366: IPR000878: IPR003754; KEGG: gme:Gmet_3235 uroporphyrinogen-III synthase/uroporphyrinogen-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
 
   
 0.571
Isop_0230
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198; KEGG: plm:Plim_1577 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
  
    0.529
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR018189: IPR000169: IPR001672; KEGG: mxa:MXAN_6908 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
    
 
 0.520
Isop_3631
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterProIPR012818: IPR014008: IPR006342: IPR006365: IPR 000878: IPR007848; KEGG: psl:Psta_2973 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; methyltransferase small; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subun [...]
     
 0.518
Isop_0668
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.500
Isop_0232
WD40-like beta Propeller containing protein; COGs: COG0823 Periplasmic component of the Tol biopolymer transport system; InterPro IPR011659; KEGG: psl:Psta_4140 WD40 domain protein beta propeller; PFAM: WD40-like beta Propeller containing protein; SPTR: WD40 domain protein beta Propeller; PFAM: WD40-like Beta Propeller Repeat.
       0.437
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
     
 0.426
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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