STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0282KEGG: min:Minf_1147 Zn-dependent hydrolase, glyoxylase family; SPTR: Putative uncharacterized protein. (88 aa)    
Predicted Functional Partners:
Isop_0280
Beta-lactamase domain-containing protein; COGs: COG0491 Zn-dependent hydrolase including glyoxylase; KEGG: pvi:Cvib_1640 beta-lactamase domain-containing protein; SPTR: Beta-lactamase domain protein; PFAM: Metallo-beta-lactamase superfamily; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
       0.558
Isop_0281
InterPro IPR011444: IPR010869; KEGG: psl:Psta_3333 protein of unknown function DUF1501; PFAM: protein of unknown function DUF1501; protein of unknown function DUF1549; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1501); Protein of unknown function (DUF1549).
       0.556
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.463
Isop_0833
Protein of unknown function DUF1802; COGs: COG4293 conserved hypothetical protein; InterPro IPR014923; KEGG: dra:DR_0097 hypothetical protein; PFAM: protein of unknown function DUF1802; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF1802).
  
     0.437
Isop_0870
COGs: COG1612 Uncharacterized protein required for cytochrome oxidase assembly; KEGG: rba:RB11934 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Cytochrome oxidase assembly protein.
  
     0.426
Isop_0461
Peptidase U32; COGs: COG0826 Collagenase and related protease; InterPro IPR001539; KEGG: psl:Psta_3009 peptidase U32; PFAM: peptidase U32; SPTR: Peptidase U32; PFAM: Collagenase; Peptidase family U32.
 
     0.425
Isop_0635
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG0348 Polyferredoxin; InterPro IPR017896: IPR017900; KEGG: hoh:Hoch_0561 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain.
     
 0.420
Isop_3584
Cytochrome c assembly protein; COGs: COG0755 ABC-type transport system involved in cytochrome c biogenesis permease component; InterPro IPR002541; KEGG: bba:Bd1606 cytochrome c-type biogenesis protein; PFAM: cytochrome c assembly protein; SPTR: Cytochrome C assembly protein; PFAM: Cytochrome C assembly protein.
  
     0.404
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.