Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0321HAD-superfamily hydrolase, subfamily IA, variant 1; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834: IPR006439; KEGG: plm:Plim_4115 HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Putative uncharacterized protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (263 aa)    
Predicted Functional Partners:
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
       0.777
Isop_0323
Glycoside hydrolase family 5; COGs: COG2730 Endoglucanase; InterPro IPR001547: IPR018087; KEGG: trq:TRQ2_1074 glycoside hydrolase family protein; PFAM: glycoside hydrolase family 5; SPTR: Glycoside hydrolase family 5; PFAM: Cellulase (glycosyl hydrolase family 5); Belongs to the glycosyl hydrolase 5 (cellulase A) family.
       0.668
Isop_0324
Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: psl:Psta_2870 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24.
       0.524
Isop_2535
Major intrinsic protein; COGs: COG0580 Glycerol uptake facilitator and related permease (Major Intrinsic Protein Family); InterPro IPR000425; KEGG: ote:Oter_1589 major intrinsic protein; PFAM: major intrinsic protein; SPTR: Major intrinsic protein; PFAM: Major intrinsic protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
    
 
 0.478
pgi
COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR018189: IPR000169: IPR001672; KEGG: mxa:MXAN_6908 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase; Belongs to the GPI family.
 
     0.466
Isop_1001
InterPro IPR001129: IPR001446; KEGG: gvi:glr3057 glutathione S-transferase; PFAM: membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG); SPTR: Glr3057 protein; PFAM: MAPEG family.
  
     0.434
Isop_0754
Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.401
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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