STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tsaDO-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (389 aa)    
Predicted Functional Partners:
Isop_3530
Uncharacterized protein family UPF0079, ATPase; COGs: COG0802 ATPase or kinase; InterPro IPR003442; KEGG: avi:Avi_0051 hypothetical protein; PFAM: Uncharacterised protein family UPF0079, ATPase; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised P-loop hydrolase UPF0079; TIGRFAM: ATPase, YjeE family.
 
 
 0.899
Isop_2566
Hypothetical protein; InterPro IPR008271; KEGG: plm:Plim_0617 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Lipopolysaccharide kinase (Kdo/WaaP) family.
  
 0.888
Isop_2608
Peptidase M22 glycoprotease; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: plm:Plim_1236 peptidase M22 glycoprotease; PFAM: peptidase M22 glycoprotease; SPTR: Peptidase M22 glycoprotease; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ.
  
 
 0.881
Isop_0321
HAD-superfamily hydrolase, subfamily IA, variant 1; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005834: IPR006439; KEGG: plm:Plim_4115 HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Putative uncharacterized protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E.
       0.777
Isop_0323
Glycoside hydrolase family 5; COGs: COG2730 Endoglucanase; InterPro IPR001547: IPR018087; KEGG: trq:TRQ2_1074 glycoside hydrolase family protein; PFAM: glycoside hydrolase family 5; SPTR: Glycoside hydrolase family 5; PFAM: Cellulase (glycosyl hydrolase family 5); Belongs to the glycosyl hydrolase 5 (cellulase A) family.
       0.668
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.616
Isop_1135
Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.
  
 0.613
cysS
COGs: COG0215 Cysteinyl-tRNA synthetase; InterPro IPR015803: IPR015273: IPR002308; KEGG: psl:Psta_3589 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; PRIAM: Cysteine--tRNA ligase; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
   
 0.577
Isop_0324
Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000994; KEGG: psl:Psta_2870 peptidase M24; PFAM: peptidase M24; SPTR: Peptidase M24; PFAM: Metallopeptidase family M24.
     
 0.575
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
 
  
 0.567
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.