STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0366NADH/Ubiquinone/plastoquinone (complex I); COGs: COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter MnhD subunit; InterPro IPR001750; KEGG: dat:HRM2_39000 HyfF; PFAM: NADH/Ubiquinone/plastoquinone (complex I); SPTR: HyfF; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains. (503 aa)    
Predicted Functional Partners:
Isop_0365
NADH dehydrogenase (ubiquinone) 30 kDa subunit; COGs: COG3261 Ni Fe-hydrogenase III large subunit; InterPro IPR001268; KEGG: geo:Geob_1700 NADH dehydrogenase (ubiquinone) 30 kDa subunit; PFAM: NADH dehydrogenase (ubiquinone) 30 kDa subunit; SPTR: NADH dehydrogenase (Ubiquinone) 30 kDa subunit; PFAM: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Respiratory-chain NADH dehydrogenase, 49 Kd subunit.
 
 
 0.998
Isop_0364
NADH ubiquinone oxidoreductase 20 kDa subunit; COGs: COG3260 Ni Fe-hydrogenase III small subunit; InterPro IPR006137: IPR017900: IPR017896; KEGG: geo:Geob_1699 NADH ubiquinone oxidoreductase 20 kDa subunit; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; SPTR: NADH ubiquinone oxidoreductase 20 kDa subunit; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit.
 
 
 0.995
Isop_0368
COGs: COG0650 Formate hydrogenlyase subunit 4; KEGG: gme:Gmet_0374 respiratory-chain NADH dehydrogenase subunit 1; SPTR: Respiratory-chain NADH dehydrogenase, subunit 1; PFAM: NADH dehydrogenase.
 
 
 0.990
Isop_0367
NAD-dependent dehydrogenase subunit; COGs: COG4237 Hydrogenase 4 membrane component (E); KEGG: dat:HRM2_38990 HyfE; SPTR: NAD-dependent dehydrogenase subunit.
 
  
 0.964
Isop_0798
NADH/Ubiquinone/plastoquinone (complex I); COGs: COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter MnhA subunit; InterPro IPR003916: IPR018393: IPR001516: IPR001750; KEGG: bra:BRADO2284 putative NADH dehydrogenase (NADH quinone oxidoreductase)(nuoL3-like); PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein; SPTR: Putative NADH dehydrogenase (NADH quinone oxidoreductase)(NuoL3-like); PFAM: NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; NADH-Ubiquinone/plastoquinone [...]
 
 
0.901
Isop_3641
Proton-translocating NADH-quinone oxidoreductase, chain L; COGs: COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter MnhA subunit; InterProIPR001516: IPR001750: IPR003945: IPR003916: IPR 018393; KEGG: plm:Plim_3868 proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH/Ubiquinone/plastoquinone (complex I); NADH-Ubiquinone oxidoreductase (complex I) chain 5/L domain protein; SPTR: Proton-translocating NADH-quinone oxidoreductase, chain L; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH-Ubiquinone/plastoq [...]
 
 
0.890
Isop_0370
PTS IIA-like nitrogen-regulatory protein PtsN; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR000551: IPR010093: IPR002178; KEGG: gur:Gura_0893 putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: regulatory protein MerR; SPTR: Putative PTS IIA-like nitrogen-regulatory protein PtsN; TIGRFAM: DNA binding domain protein, excisionase family; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; TIGRFAM: DNA binding domain, excisionase family.
 
     0.870
Isop_0369
NADH/Ubiquinone/plastoquinone (complex I); COGs: COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter MnhD subunit; InterPro IPR001750: IPR003918; KEGG: dat:HRM2_38970 HyfB; PFAM: NADH/Ubiquinone/plastoquinone (complex I); SPTR: HyfB; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains.
 
    
0.845
Isop_0635
4Fe-4S ferredoxin iron-sulfur binding domain protein; COGs: COG0348 Polyferredoxin; InterPro IPR017896: IPR017900; KEGG: hoh:Hoch_0561 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain.
  
 
 0.709
nuoB
NADH-quinone oxidoreductase, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
 
 
 
 0.647
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.