Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0425AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterProIPR003338: IPR004201: IPR003959: IPR003593: IPR 003960: IPR005938; KEGG: mxa:MXAN_2773 AAA family ATPase; PFAM: AAA ATPase central domain protein; AAA ATPase VAT domain protein; cell division protein 48 CDC48 domain 2; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: ATPase, AAA family; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), N-terminal domain; Cell division protein 48 (CDC48), domain 2; [...] (845 aa)    
Predicted Functional Partners:
Isop_2908
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: cag:Cagg_1601 histone deacetylase superfamily; PFAM: histone deacetylase superfamily; PRIAM: Histone deacetylase; SPTR: Histone deacetylase superfamily; PFAM: Histone deacetylase domain.
   
 0.905
Isop_0426
KEGG: pin:Ping_1246 heat shock protein, HSP20 family protein; SPTR: Heat shock protein, HSP20 family protein.
  
 
 0.820
Isop_0191
KEGG: xcb:XC_0878 protein kinases, catalytic domain; region: PKc_like; cl09925; SPTR: Putative uncharacterized protein.
   
 0.818
Isop_2985
Ankyrin; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110: IPR020683; KEGG: sin:YN1551_2013 ankyrin; PFAM: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat.
    
 0.809
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 
 0.793
Isop_3698
KEGG: scl:sce3364 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 
 0.781
Isop_3264
KEGG: mar:MAE_47620 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Dynamin family.
  
 
 
 0.769
Isop_2535
Major intrinsic protein; COGs: COG0580 Glycerol uptake facilitator and related permease (Major Intrinsic Protein Family); InterPro IPR000425; KEGG: ote:Oter_1589 major intrinsic protein; PFAM: major intrinsic protein; SPTR: Major intrinsic protein; PFAM: Major intrinsic protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
    
   0.754
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
  0.752
Isop_0768
Gas vesicle protein GvpN; COGs: COG0714 MoxR-like ATPase; InterPro IPR011704: IPR013462: IPR003593; KEGG: cya:CYA_0826 gas vesicle protein GvpN; PFAM: ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; SPTR: Gas vesicle protein GvpN; TIGRFAM: gas vesicle protein GvpN; PFAM: AAA domain (dynein-related subfamily); CbbQ/NirQ/NorQ C-terminal; TIGRFAM: gas vesicle protein GvpN.
 
     0.719
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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