STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Isop_0474Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: rba:RB2626 hypothetical protein; PFAM: Methyltransferase type 11; SPTR: Putative uncharacterized protein; PFAM: Methyltransferase domain. (284 aa)    
Predicted Functional Partners:
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR002314: IPR004154: IPR004516: IPR015807: IPR 006195; KEGG: rba:RB251 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase.
       0.618
Isop_0472
tRNA synthetase class II (G H P and S); COGs: COG0124 Histidyl-tRNA synthetase; InterPro IPR002314: IPR006195; KEGG: hau:Haur_3835 histidine--tRNA ligase; PFAM: tRNA synthetase class II (G H P and S); SPTR: Histidine--tRNA ligase; PFAM: tRNA synthetase class II core domain (G, H, P, S and T).
       0.618
Isop_0473
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
       0.618
Isop_0361
KEGG: nda:Ndas_3773 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0104).
  
     0.494
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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