STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (685 aa)    
Predicted Functional Partners:
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.992
Isop_2538
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR001650: IPR006474: IPR006483; KEGG: mba:Mbar_A3123 hypothetical protein; PFAM: helicase domain protein; SMART: helicase domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated helicase Cas3, Anaes-subtype; CRISPR-associated endonuclease Cas3-HD.
 
  
 0.894
Isop_0512
CRISPR-associated protein, GSU0054; InterPro IPR019089; KEGG: hoh:Hoch_4849 hypothetical protein; PFAM: CRISPR-associated protein, GSU0054; SPTR: Putative uncharacterized protein; manually curated; PFAM: CRISPR-associated protein, GSU0054 family (Cas_GSU0054).
 
   
 0.887
Isop_1832
COGs: COG1203 helicase; InterPro IPR013444: IPR006483; KEGG: hoh:Hoch_4850 CRISPR-associated helicase Cas3, Anaes-subtype; SPTR: CRISPR-associated helicase Cas3, Anaes-subtype; TIGRFAM: CRISPR-associated helicase Cas3, Anaes-subtype; CRISPR-associated HD domain protein; TIGRFAM: CRISPR-associated endonuclease Cas3-HD; CRISPR-associated helicase Cas3, Anaes-subtype.
 
  
 0.881
Isop_2541
CRISPR-associated protein, GSU0054; InterPro IPR019089; KEGG: bts:Btus_2681 CRISPR-associated protein; PFAM: CRISPR-associated protein, GSU0054; SPTR: Putative uncharacterized protein; PFAM: CRISPR-associated protein, GSU0054 family (Cas_GSU0054).
 
   
 0.817
Isop_2540
CRISPR-associated protein GSU0053; InterPro IPR013403; KEGG: tgr:Tgr7_2440 hypothetical protein; PFAM: CRISPR-associated protein GSU0053; SPTR: Putative uncharacterized protein; PFAM: CRISPR-associated protein GSU0053 (Cas_GSU0053); TIGRFAM: CRISPR-associated protein, GSU0053 family, N-terminal domain.
 
   
 0.815
Isop_2539
KEGG: tgr:Tgr7_2441 hypothetical protein; SPTR: Putative uncharacterized protein.
 
     0.797
Isop_1834
CRISPR-associated protein, Csx4 family; InterPro IPR013403; KEGG: hoh:Hoch_4848 CRISPR-associated protein GSU0053; PFAM: CRISPR-associated protein GSU0053; SPTR: CRISPR-associated protein GSU0053; PFAM: CRISPR-associated protein GSU0053 (Cas_GSU0053); TIGRFAM: CRISPR-associated protein, GSU0053 family, N-terminal domain.
 
   
 0.786
Isop_1833
CRISPR-associated protein, GSU0054; InterPro IPR019089; KEGG: hoh:Hoch_4849 hypothetical protein; PFAM: CRISPR-associated protein, GSU0054; SPTR: Putative uncharacterized protein; PFAM: CRISPR-associated protein, GSU0054 family (Cas_GSU0054); TIGRFAM: CRISPR-associated protein, GSU0054 family.
 
   
 0.689
Isop_2148
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013410: IPR005537; KEGG: rce:RC1_3484 CRISPR-associated RAMP protein, putative; PFAM: protein of unknown function DUF324; SPTR: CRISPR-associated RAMP protein, putative; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; PFAM: RAMP superfamily; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family.
 
     0.654
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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