Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0512CRISPR-associated protein, GSU0054; InterPro IPR019089; KEGG: hoh:Hoch_4849 hypothetical protein; PFAM: CRISPR-associated protein, GSU0054; SPTR: Putative uncharacterized protein; manually curated; PFAM: CRISPR-associated protein, GSU0054 family (Cas_GSU0054). (372 aa)    
Predicted Functional Partners:
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.887
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
     0.873
Isop_1834
CRISPR-associated protein, Csx4 family; InterPro IPR013403; KEGG: hoh:Hoch_4848 CRISPR-associated protein GSU0053; PFAM: CRISPR-associated protein GSU0053; SPTR: CRISPR-associated protein GSU0053; PFAM: CRISPR-associated protein GSU0053 (Cas_GSU0053); TIGRFAM: CRISPR-associated protein, GSU0053 family, N-terminal domain.
 
  
 0.789
Isop_1832
COGs: COG1203 helicase; InterPro IPR013444: IPR006483; KEGG: hoh:Hoch_4850 CRISPR-associated helicase Cas3, Anaes-subtype; SPTR: CRISPR-associated helicase Cas3, Anaes-subtype; TIGRFAM: CRISPR-associated helicase Cas3, Anaes-subtype; CRISPR-associated HD domain protein; TIGRFAM: CRISPR-associated endonuclease Cas3-HD; CRISPR-associated helicase Cas3, Anaes-subtype.
 
    0.784
Isop_2538
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR001650: IPR006474: IPR006483; KEGG: mba:Mbar_A3123 hypothetical protein; PFAM: helicase domain protein; SMART: helicase domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated helicase Cas3, Anaes-subtype; CRISPR-associated endonuclease Cas3-HD.
 
    0.664
Isop_2506
KEGG: plm:Plim_3939 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.662
Isop_0537
Repeat-companion domain protein; InterPro IPR003590: IPR014338; KEGG: hau:Haur_4051 hypothetical protein; SPTR: Leucine-rich repeat-containing protein typical subtype; TIGRFAM: repeat-companion domain protein; TIGRFAM: repeat-companion domain TIGR02996.
  
     0.661
Isop_3202
Hypothetical protein; KEGG: ttu:TERTU_3103 putative type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: Putative type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase.
  
     0.593
Isop_0912
Hypothetical protein; InterPro IPR009056; KEGG: noc:Noc_1610 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.571
Isop_0513
Penicillinase repressor; InterPro IPR005650; KEGG: hoh:Hoch_4716 transcriptional repressor, CopY family; PFAM: Penicillinase repressor; SPTR: Transcriptional repressor, CopY family protein; PFAM: Penicillinase repressor.
       0.564
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.