Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0527Short-chain dehydrogenase/reductase SDR; COGs: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; InterPro IPR002198: IPR002347; KEGG: psl:Psta_0898 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Oxidoreductase, short-chain dehydrogenase/reductase family protein; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)    
Predicted Functional Partners:
Isop_2060
Thioester reductase domain protein; COGs: COG3320 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetase; InterPro IPR013120: IPR010080; KEGG: mxa:MXAN_4525 non-ribosomal peptide synthase MxaA; PFAM: Male sterility domain; SPTR: MxaA; TIGRFAM: thioester reductase domain protein; PFAM: Male sterility protein; TIGRFAM: thioester reductase domain.
      0.902
Isop_2032
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198: IPR002347; KEGG: psl:Psta_2635 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
 
  
 0.774
Isop_0180
Amino acid adenylation domain protein; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR010071: IPR020845: IPR000873; KEGG: eba:ebA4326 putative acyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: Putative acyl-CoA synthetase; TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-binding enzyme; TIGRFAM: amino acid adenylation domain; Belongs to the ATP-dependent AMP-binding enzyme family.
 
  
 0.767
Isop_0230
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198; KEGG: plm:Plim_1577 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
 
  
 0.765
Isop_0016
KEGG: eba:ebA1583 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.535
Isop_1932
Thiol peroxidase (atypical 2-Cys peroxiredoxin); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
   
    0.508
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
  
  
 0.503
Isop_2488
Protein of unknown function DUF1446; InterPro IPR010839; KEGG: sus:Acid_3874 hypothetical protein; PFAM: protein of unknown function DUF1446; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1446).
  
  
 0.419
Isop_0526
KEGG: psl:Psta_0848 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.417
Isop_0528
InterPro IPR000209; KEGG: cyt:cce_1400 hypothetical protein; PFAM: peptidase S8 and S53 subtilisin kexin sedolisin; SPTR: Major intracellular serine protease; PFAM: Subtilase family.
       0.405
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.