Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0543AAA ATPase central domain protein; COGs: COG0465 ATP-dependent Zn protease; InterPro IPR003959: IPR000642: IPR003593: IPR003960; KEGG: mxa:MXAN_2898 ATP-dependent metalloprotease FtsH; PFAM: AAA ATPase central domain protein; peptidase M41; SMART: AAA ATPase; SPTR: ATP-dependent metalloprotease, FtsH family; PFAM: Peptidase family M41; ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family. (750 aa)    
Predicted Functional Partners:
atpA
ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
   
 0.773
rpsK
SSU ribosomal protein S11P; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
  
 
 0.758
rplN
LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
  
 
 0.732
rplB
LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
 
 0.723
Isop_1789
SPFH domain, Band 7 family protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001972: IPR001107; KEGG: pca:Pcar_2837 membrane protease subunit, stomatin/prohibitin-like; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Putative uncharacterized protein; PFAM: SPFH domain / Band 7 family.
   
 0.711
Isop_2978
Band 7 protein; InterPro IPR001107; KEGG: psl:Psta_4418 band 7 protein; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Band 7 protein; PFAM: SPFH domain / Band 7 family.
   
 0.711
Isop_3000
Band 7 protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107; KEGG: llo:LLO_1401 hypothetical protein, SPFH domain/band 7 family; PFAM: band 7 protein; SMART: band 7 protein; SPTR: Putative uncharacterized protein; PFAM: SPFH domain / Band 7 family.
   
 0.711
rpsE
SSU ribosomal protein S5P; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.
  
 
 0.708
rpsG
SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
   0.706
Isop_1836
COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836: IPR005904; KEGG: psl:Psta_1642 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.700
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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