STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0643Peptidase A24A prepilin type IV; InterPro IPR000045; KEGG: plm:Plim_1841 peptidase A24A domain protein; PFAM: peptidase A24A prepilin type IV; SPTR: Probable type 4 prepilin-like proteins leader peptide processing enzyme; PFAM: Type IV leader peptidase family. (323 aa)    
Predicted Functional Partners:
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA); Belongs to the type-I 3-dehydroquinase family.
  
  
 0.882
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
     
 0.806
Isop_2397
COGs: COG0658 membrane metal-binding protein; InterPro IPR004477: IPR000073; KEGG: rba:RB9840 competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; alpha/beta hydrolase fold; SPTR: Probable competence protein; TIGRFAM: ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; X-Pro dipeptidyl-peptidase (S15 family); TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
  
  
 0.761
Isop_2952
Peptidase A24A domain protein; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627; KEGG: plm:Plim_1574 peptidase A24A domain protein; PFAM: peptidase A24A domain protein; SPTR: Peptidase A24A domain protein; PFAM: Bacterial Peptidase A24 N-terminal domain.
  
     0.680
Isop_1820
DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: psl:Psta_1070 DNA protecting protein DprA; PFAM: SMF family protein; SPTR: DNA processing chain A; TIGRFAM: DNA protecting protein DprA; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.
  
  
 0.678
Isop_2822
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004: IPR018076; KEGG: plm:Plim_0407 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.
 
  
 0.627
Isop_0260
COGs: COG1555 DNA uptake protein and related DNA-binding protein; InterPro IPR003583; KEGG: plm:Plim_2967 helix-hairpin-helix DNA-binding class 1; SMART: Helix-hairpin-helix DNA-binding class 1; SPTR: Helix-hairpin-helix DNA-binding class 1; TIGRFAM: competence protein ComEA helix-hairpin-helix repeat region.
   
  
 0.604
Isop_0791
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004: IPR018076; KEGG: ank:AnaeK_0718 general secretion pathway protein F; PFAM: Type II secretion system F domain; SPTR: General secretion pathway protein F; PFAM: Bacterial type II secretion system protein F domain.
 
  
 0.579
Isop_1358
KEGG: plm:Plim_0058 putative membrane bound transporter; SPTR: Putative uncharacterized protein.
 
     0.523
Isop_2819
Type II secretion system protein E (GspE); COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR003593: IPR007831: IPR001482; KEGG: rba:RB12768 type IV fimbrial assembly protein PilB; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; SMART: AAA ATPase; SPTR: Type IV fimbrial assembly protein PilB; PFAM: Type II/IV secretion system protein; GSPII_E N-terminal domain; TIGRFAM: general secretory pathway protein E.
 
 
 0.518
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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