STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Isop_0683COGs: COG0460 Homoserine dehydrogenase; InterProIPR005106: IPR001342: IPR002912: IPR016204: IPR 019811; KEGG: rba:RB8510 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; SPTR: Homoserine dehydrogenase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain. (444 aa)    
Predicted Functional Partners:
asd
Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 0.970
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.939
Isop_0668
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.936
Isop_0584
COGs: COG0527 Aspartokinase; InterProIPR001048: IPR002912: IPR018042: IPR005260: IPR 001341; KEGG: psl:Psta_4303 aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; SPTR: Aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase.
 
 0.935
Isop_0351
COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: rca:Rcas_2758 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; PFAM: Cobalamin-independent synthase, Catalytic domain.
   
 
 0.871
Isop_1329
COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: psl:Psta_4420 serine O-acetyltransferase; PRIAM: Serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: serine O-acetyltransferase.
  
  
 0.851
Isop_1131
Homocysteine S-methyltransferase; COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: ade:Adeh_1778 homocysteine S-methyltransferase; PFAM: homocysteine S-methyltransferase; SPTR: Homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase.
  
 
 0.847
Isop_1176
Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: ppp:PHYPADRAFT_141539 hypothetical protein; PFAM: aminotransferase class IV; SPTR: Putative branched chain amino acid aminotransferase; PFAM: Aminotransferase class IV.
  
 
 0.847
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.847
Isop_3195
Putative serineacetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451; KEGG: scl:sce5074 putative serineacetyltransferase; SPTR: Putative serineacetyltransferase.
     
 0.819
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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