Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0732Signal peptidase I; InterPro IPR000223: IPR019759: IPR019757: IPR019758; KEGG: plm:Plim_1125 peptidase S24 and S26 domain protein; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Probable signal peptidase I; TIGRFAM: signal peptidase I; PFAM: Peptidase S24-like; TIGRFAM: signal peptidase I, bacterial type; Belongs to the peptidase S26 family. (535 aa)    
Predicted Functional Partners:
lepA
GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.892
Isop_3563
Tetratricopeptide TPR_1 repeat-containing protein; InterPro IPR019734: IPR013026: IPR001440; KEGG: plm:Plim_0726 hypothetical protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SMART: Tetratricopeptide repeat; SPTR: Putative uncharacterized protein.
 
  
 0.710
Isop_0733
Peptidase S24/S26A/S26B, conserved region; InterPro IPR000223: IPR019759: IPR019757: IPR019758; KEGG: plm:Plim_1125 peptidase S24 and S26 domain protein; PFAM: Peptidase S24/S26A/S26B, conserved region; SPTR: Peptidase S24 and S26 domain protein; PFAM: Peptidase S24-like.
 
    
0.666
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
  
 0.656
Isop_1036
COGs: COG4972 Tfp pilus assembly protein ATPase PilM; InterPro IPR005883; KEGG: plm:Plim_0076 type IV pilus assembly protein PilM; SPTR: Probable fimbrial assembly protein PilM; TIGRFAM: type IV pilus assembly protein PilM; PFAM: Competence protein A; Cell division protein FtsA; TIGRFAM: type IV pilus assembly protein PilM.
 
     0.539
Isop_2313
PEGA domain protein; InterPro IPR013229; KEGG: plm:Plim_2448 PEGA domain protein; PFAM: PEGA domain protein; SPTR: PEGA domain protein; PFAM: PEGA domain.
  
     0.534
Isop_1769
KEGG: rba:RB11569 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.529
Isop_2377
KEGG: plm:Plim_0704 hypothetical protein; SPTR: Putative uncharacterized protein.
 
    0.503
Isop_2214
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.489
Isop_0681
Glycoside hydrolase family 10; COGs: COG3693 Beta-1 4-xylanase; KEGG: plm:Plim_3847 glycoside hydrolase family 10; SPTR: Glycoside hydrolase family 10.
  
     0.486
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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