STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Isop_0771Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198; KEGG: syx:SynWH7803_2446 short-chain dehydrogenase/reductase of unknown specificity; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase (SDR) superfamily protein; PFAM: short chain dehydrogenase. (317 aa)    
Predicted Functional Partners:
Isop_0772
COGs: COG0076 Glutamate decarboxylase and related PLP-dependent protein; InterPro IPR002129; KEGG: mca:MCA2806 pyridoxal-dependent decarboxylase domain-containing protein; PFAM: Pyridoxal-dependent decarboxylase; SPTR: Pyridoxal-dependent decarboxylase domain protein; PFAM: Pyridoxal-dependent decarboxylase conserved domain.
     
 0.735
Isop_1507
Short-chain dehydrogenase/reductase SDR; COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198: IPR020904: IPR002347; KEGG: cyb:CYB_0005 short chain dehydrogenase/reductase family oxidoreductase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Oxidoreductase, short chain dehydrogenase/reductase family; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
   0.592
Isop_2985
Ankyrin; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110: IPR020683; KEGG: sin:YN1551_2013 ankyrin; PFAM: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat.
    
 0.539
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.521
Isop_2108
Short-chain dehydrogenase/reductase SDR; COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198: IPR002347; KEGG: ade:Adeh_3849 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
   0.484
Isop_2748
COGs: COG0183 Acetyl-CoA acetyltransferase; InterProIPR020615: IPR020610: IPR001412: IPR020613: IPR 020616: IPR020617: IPR002155; KEGG: gau:GAU_1289 acetyl-CoA acetyltransferase; PFAM: Thiolase-like; PRIAM: Acetyl-CoA C-acetyltransferase; SPTR: Acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.464
Isop_1293
COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130: IPR011506: IPR001343; KEGG: psl:Psta_1955 peptidyl-prolyl cis-trans isomerase cyclophilin type; PFAM: peptidyl-prolyl cis-trans isomerase cyclophilin type; Planctomycete extracellular domain protein; Hemolysin-type calcium-binding region; SPTR: Peptidyl-prolyl cis-trans isomerase cyclophilin type; PFAM: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD.
  
 
   0.457
Isop_1426
Short-chain dehydrogenase/reductase SDR; COGs: COG0300 Short-chain dehydrogenase of various substrate specificities; InterPro IPR002198: IPR020904: IPR002347; KEGG: psl:Psta_3581 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Glucose 1-dehydrogenase-like protein; PFAM: short chain dehydrogenase.
  
 
   0.455
Isop_2032
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198: IPR002347; KEGG: psl:Psta_2635 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
  
     0.427
Isop_2765
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR020904: IPR002198; KEGG: sli:Slin_5818 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
  
     0.416
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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