STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_0772COGs: COG0076 Glutamate decarboxylase and related PLP-dependent protein; InterPro IPR002129; KEGG: mca:MCA2806 pyridoxal-dependent decarboxylase domain-containing protein; PFAM: Pyridoxal-dependent decarboxylase; SPTR: Pyridoxal-dependent decarboxylase domain protein; PFAM: Pyridoxal-dependent decarboxylase conserved domain. (534 aa)    
Predicted Functional Partners:
Isop_0771
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002347: IPR002198; KEGG: syx:SynWH7803_2446 short-chain dehydrogenase/reductase of unknown specificity; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase (SDR) superfamily protein; PFAM: short chain dehydrogenase.
     
 0.735
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.485
Isop_3506
KEGG: gox:GOX1189 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 
 0.403
Isop_0123
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR002872: IPR015590; KEGG: psl:Psta_0870 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; SPTR: 1-pyrroline-5 carboxylate dehydrogenase; PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Belongs to the aldehyde dehydrogenase family.
   
 
 0.401
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.