Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0828Sugar isomerase (SIS); COGs: COG0279 Phosphoheptose isomerase; InterPro IPR001347; KEGG: plm:Plim_1528 sugar isomerase (SIS); PFAM: sugar isomerase (SIS); SPTR: Sugar isomerase (SIS); PFAM: SIS domain. (203 aa)    
Predicted Functional Partners:
hldE
D-alpha,beta-D-heptose 7-phosphate 1-kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
  
 0.982
Isop_3060
COGs: COG0859 ADP-heptose:LPS heptosyltransferase; InterPro IPR011908: IPR011910: IPR002201; KEGG: plm:Plim_1964 glycosyl transferase family 9; PFAM: glycosyl transferase family 9; SPTR: Heptosyltransferase family protein; TIGRFAM: lipopolysaccharide heptosyltransferase I; lipopolysaccharide heptosyltransferase II; PFAM: Glycosyltransferase family 9 (heptosyltransferase); TIGRFAM: lipopolysaccharide heptosyltransferase I; lipopolysaccharide heptosyltransferase II.
 
   
 0.788
Isop_0980
COGs: COG0859 ADP-heptose:LPS heptosyltransferase; InterPro IPR002201; KEGG: pca:Pcar_1263 ADP-heptose--LPS heptosyltransferase II; PFAM: glycosyl transferase family 9; SPTR: Lipopolysaccharide heptosyltransferase II; manually curated; PFAM: Glycosyltransferase family 9 (heptosyltransferase); TIGRFAM: lipopolysaccharide heptosyltransferase II.
 
   
 0.787
Isop_1281
Lipopolysaccharide heptosyltransferase II; COGs: COG0859 ADP-heptose:LPS heptosyltransferase; InterPro IPR011910: IPR002201; KEGG: plm:Plim_0899 lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; SPTR: ADP-heptose--LPS heptosyltransferase II, putative; TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: Glycosyltransferase family 9 (heptosyltransferase); TIGRFAM: lipopolysaccharide heptosyltransferase II.
 
   
 0.781
hldD
ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
 
  
 0.740
Isop_0829
ROK family protein; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR000600; KEGG: plm:Plim_1388 ROK family protein; PFAM: ROK family protein; SPTR: ROK protein; PFAM: ROK family.
       0.715
Isop_0131
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR000644: IPR004800: IPR018506: IPR001347; KEGG: psl:Psta_0845 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SPTR: KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein.
 
   
 0.639
Isop_0824
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR005835; KEGG: rrs:RoseRS_4077 nucleotidyl transferase; PFAM: Nucleotidyl transferase; SPTR: Nucleotidyl transferase; PFAM: Nucleotidyl transferase.
  
  
 0.562
Isop_0826
Hypothetical protein; KEGG: pca:Pcar_1265 putative LPS biosynthesis enzyme; SPTR: Mn2+-dependent serine/threonine protein kinase; PFAM: Lipopolysaccharide kinase (Kdo/WaaP) family.
 
     0.555
Isop_0825
COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: sfu:Sfum_0373 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Probable glycosyltransferase; PFAM: Glycosyl transferases group 1.
 
     0.523
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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