Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_0999Domain of unknown function DUF1731; COGs: COG1090 nucleoside-diphosphate sugar epimerase; InterPro IPR010099: IPR001509: IPR013549; KEGG: cwo:Cwoe_2865 domain of unknown function DUF1731; PFAM: domain of unknown function DUF1731; NAD-dependent epimerase/dehydratase; SPTR: Putative uncharacterized protein; manually curated; PFAM: NAD dependent epimerase/dehydratase family; Domain of unknown function (DUF1731); TIGRFAM: conserved hypothetical protein TIGR01777. (346 aa)    
Predicted Functional Partners:
Isop_2757
Cyclase/dehydrase; COGs: COG4276 conserved hypothetical protein; InterPro IPR005031; KEGG: scl:sce1328 hypothetical protein; PFAM: cyclase/dehydrase; SPTR: Putative uncharacterized protein; PFAM: Polyketide cyclase / dehydrase and lipid transport.
     0.864
Isop_1000
Hypothetical protein; KEGG: aav:Aave_1628 prophage tail length tape measure; SPTR: Prophage tail length tape measure.
       0.550
Isop_3323
Zinc/iron permease; InterPro IPR003689; KEGG: psl:Psta_1336 zinc/iron permease; PFAM: zinc/iron permease; SPTR: Metal cation transporter, ZIP family; PFAM: ZIP Zinc transporter.
  
    0.540
Isop_1060
ABC-3 protein; COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001367: IPR001626; KEGG: psl:Psta_4677 ABC-3 protein; PFAM: ABC-3 protein; iron dependent repressor; SMART: iron dependent repressor; SPTR: ABC-3 protein; PFAM: ABC 3 transport family; Iron dependent repressor, metal binding and dimerisation domain.
   
    0.470
Isop_1370
Iron (metal) dependent repressor, DtxR family; COGs: COG1321 Mn-dependent transcriptional regulator protein; InterPro IPR001367: IPR007167; KEGG: psl:Psta_3183 iron (metal) dependent repressor, DtxR family; PFAM: iron dependent repressor; FeoA family protein; SMART: iron dependent repressor; SPTR: Iron (Metal) dependent repressor, DtxR family; PFAM: FeoA domain; Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain.
   
    0.470
Isop_2995
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394: IPR007046: IPR007634; KEGG: psl:Psta_2523 RNA polymerase, sigma 54 subunit, RpoN; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: RNA polymerase, sigma 54 subunit, RpoN; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54 factor, core binding domain; Sigma-54, DNA binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
   
    0.422
Isop_2760
Phosphate uptake regulator, PhoU; Plays a role in the regulation of phosphate uptake.
   
    0.419
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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