STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_1013Formaldehyde-activating enzyme; COGs: COG1795 conserved hypothetical protein; InterPro IPR014826; KEGG: plm:Plim_1285 formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); SPTR: Formaldehyde-activating enzyme; TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); TIGRFAM: formaldehyde-activating enzyme. (167 aa)    
Predicted Functional Partners:
Isop_1012
InterPro IPR015259; KEGG: psl:Psta_2659 methylenetetrahydrofolate dehydrogenase (NADP(+)); PFAM: Methylene-tetrahydromethanopterin dehydrogenase; PRIAM: Methylenetetrahydrofolate dehydrogenase (NADP(+)); SPTR: Methylenetetrahydrofolate dehydrogenase (NADP(+)); PFAM: Methylene-tetrahydromethanopterin dehydrogenase, N-terminal.
 
  
 0.987
ffsA
Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
  
 0.979
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.913
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
   
 0.820
Isop_0151
COGs: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; InterPro IPR002736; KEGG: psl:Psta_4265 triphosphoribosyl-dephospho-CoA protein; PFAM: triphosphoribosyl-dephospho-CoA protein; SPTR: Triphosphoribosyl-dephospho-CoA protein; PFAM: ATP:dephospho-CoA triphosphoribosyl transferase.
 
   
 0.798
Isop_2074
Protein of unknown function DUF201; COGs: COG2232 ATP-dependent carboligase related to biotin carboxylase; InterPro IPR003806: IPR011761; KEGG: met:M446_5779 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: Putative uncharacterized protein; PFAM: ATP-grasp domain.
 
   
 0.798
Isop_3055
COGs: COG1907 sugar kinase; InterPro IPR004422; KEGG: xau:Xaut_3535 beta-ribofuranosylaminobenzene 5'-phosphate synthase; SPTR: Beta-ribofuranosylaminobenzene 5'-phosphate synthase family; TIGRFAM: beta-ribofuranosylaminobenzene 5'-phosphate synthase family; PFAM: GHMP kinases C terminal; TIGRFAM: beta-RFAP synthase.
 
     0.790
Isop_0326
COGs: COG2218 Formylmethanofuran dehydrogenase subunit C; InterPro IPR002489: IPR017550; KEGG: nhl:Nhal_0012 formylmethanofuran dehydrogenase subunit C; PFAM: glutamate synthase alpha subunit domain protein; PRIAM: Formylmethanofuran dehydrogenase; SPTR: Formylmethanofuran dehydrogenase subunit C; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C.
 
     0.789
Isop_0524
COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR013108: IPR012027; KEGG: psl:Psta_0063 formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; SPTR: Formylmethanofuran dehydrogenase subunit A; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A.
 
     0.789
Isop_2656
Hypothetical protein; COGs: COG1029 Formylmethanofuran dehydrogenase subunit B; KEGG: plm:Plim_2299 formylmethanofuran dehydrogenase subunit B-like protein; SPTR: Formyltransferase/hydrolase complex subunit B.
 
     0.782
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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