Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Isop_1021Twitching motility protein; COGs: COG2805 Tfp pilus assembly protein pilus retraction ATPase PilT; InterPro IPR006321: IPR001482; KEGG: psl:Psta_1744 twitching motility protein; PFAM: type II secretion system protein E; SPTR: Twitching motility protein; TIGRFAM: twitching motility protein; PFAM: Type II/IV secretion system protein; TIGRFAM: pilus retraction protein PilT. (397 aa)    
Predicted Functional Partners:
Isop_0791
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004: IPR018076; KEGG: ank:AnaeK_0718 general secretion pathway protein F; PFAM: Type II secretion system F domain; SPTR: General secretion pathway protein F; PFAM: Bacterial type II secretion system protein F domain.
 
  
 0.800
Isop_2822
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004: IPR018076; KEGG: plm:Plim_0407 type II secretion system protein; PFAM: Type II secretion system F domain; SPTR: Type IV fimbrial assembly protein PilC; PFAM: Bacterial type II secretion system protein F domain.
 
  
 0.800
Isop_2952
Peptidase A24A domain protein; COGs: COG1989 Type II secretory pathway prepilin signal peptidase PulO and related peptidase; InterPro IPR010627; KEGG: plm:Plim_1574 peptidase A24A domain protein; PFAM: peptidase A24A domain protein; SPTR: Peptidase A24A domain protein; PFAM: Bacterial Peptidase A24 N-terminal domain.
 
   
 0.793
Isop_1022
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR001482; KEGG: plm:Plim_0082 type II secretion system protein E; PFAM: type II secretion system protein E; SPTR: Type II secretion system protein E; PFAM: Type II/IV secretion system protein.
 
  
0.646
Isop_1036
COGs: COG4972 Tfp pilus assembly protein ATPase PilM; InterPro IPR005883; KEGG: plm:Plim_0076 type IV pilus assembly protein PilM; SPTR: Probable fimbrial assembly protein PilM; TIGRFAM: type IV pilus assembly protein PilM; PFAM: Competence protein A; Cell division protein FtsA; TIGRFAM: type IV pilus assembly protein PilM.
 
   
 0.563
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
       0.527
Isop_2397
COGs: COG0658 membrane metal-binding protein; InterPro IPR004477: IPR000073; KEGG: rba:RB9840 competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; alpha/beta hydrolase fold; SPTR: Probable competence protein; TIGRFAM: ComEC/Rec2-related protein; PFAM: Competence protein; Metallo-beta-lactamase superfamily; X-Pro dipeptidyl-peptidase (S15 family); TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence protein ComEC/Rec2.
     
 0.487
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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