Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
Isop_1033COGs: COG0515 Serine/threonine protein kinase; InterProIPR020635: IPR002290: IPR000719: IPR017442: IPR 002355: IPR017441: IPR008271; KEGG: psl:Psta_4528 serine/threonine protein kinase; PFAM: Serine/threonine-protein kinase-like domain; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, catalytic domain; SPTR: Serine/threonine protein kinase; PFAM: Protein kinase domain. (1309 aa)    
Predicted Functional Partners:
Isop_3004
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR001932: IPR014045: IPR010822; KEGG: psl:Psta_1567 protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C-like; Stage II sporulation protein E; SMART: protein phosphatase 2C domain protein; SPTR: Protein serine/threonine phosphatase; PFAM: Protein phosphatase 2C.
 
 
 0.818
Isop_3386
COGs: COG0631 Serine/threonine protein phosphatase; InterPro IPR014045: IPR001932; KEGG: plm:Plim_2397 phosphoprotein phosphatase; PFAM: Protein phosphatase 2C-like; SMART: protein phosphatase 2C domain protein; SPTR: Protein phosphatase; PFAM: Protein phosphatase 2C.
 
 
 0.817
Isop_0501
COGs: COG0515 Serine/threonine protein kinase; InterProIPR017442: IPR002290: IPR017441: IPR008271: IPR 000719; KEGG: rba:RB5593 serine/threonine-protein kinase; PFAM: Serine/threonine-protein kinase-like domain; SMART: serine/threonine protein kinase; SPTR: Serine/threonine-protein kinase; PFAM: Protein kinase domain.
  
     0.749
Isop_3158
Cyclic nucleotide-binding protein; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR017900: IPR018528: IPR018488: IPR002373: IPR 000595: IPR001041: IPR017896; KEGG: sus:Acid_4310 cyclic nucleotide-binding protein; PFAM: cyclic nucleotide-binding; ferredoxin; SMART: cyclic nucleotide-binding; SPTR: Cyclic nucleotide-binding protein; PFAM: Cyclic nucleotide-binding domain.
  
 
 0.729
Isop_0055
Cyclic nucleotide-binding protein; InterPro IPR000595; KEGG: tcr:504449.30 hypothetical protein; PFAM: cyclic nucleotide-binding; SPTR: Putative uncharacterized protein; PFAM: Cyclic nucleotide-binding domain.
  
 
 0.658
Isop_1846
KEGG: psl:Psta_4608 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 0.610
Isop_1972
COGs: COG0642 Signal transduction histidine kinase; InterProIPR013655: IPR013767: IPR003661: IPR003594: IPR 001789: IPR008207: IPR000014: IPR004358: IPR000896: IPR005467; KEGG: rba:RB159 sensory transduction histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold domain protein; Hpt domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; SPTR: Sensory transduction histidine k [...]
   
 
 0.610
Isop_3271
COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358: IPR000014: IPR001610: IPR003661: IPR 003594: IPR001789: IPR005467: IPR000700: IPR008207: IPR013767; KEGG: psl:Psta_1412 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; PAC repeat-containing protein; response regulator receiver; SPTR: PAS/PAC sensor hybrid h [...]
   
 
 0.607
Isop_2966
COGs: COG0642 Signal transduction histidine kinase; InterProIPR000253: IPR005467: IPR004358: IPR003018: IPR 003594; KEGG: psl:Psta_3175 GAF sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; Forkhead-associated protein; GAF domain protein; SMART: ATP-binding region ATPase domain protein; GAF domain protein; Forkhead-associated protein; SPTR: GAF sensor signal transduction histidine kinase; PFAM: GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; FHA domain.
  
 
 0.606
Isop_2985
Ankyrin; COGs: COG0666 FOG: Ankyrin repeat; InterPro IPR002110: IPR020683; KEGG: sin:YN1551_2013 ankyrin; PFAM: Ankyrin; SPTR: Ankyrin; PFAM: Ankyrin repeat.
   
 
 0.598
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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