STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
cutCCutC family protein; Participates in the control of copper homeostasis. Belongs to the CutC family. (287 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
   
   0.669
ADV62283.1
COGs: COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; InterPro IPR018321: IPR006148; KEGG: coc:Coch_2021 glucosamine-6-phosphate deaminase-like protein; PFAM: glucosamine/galactosamine-6-phosphate isomerase; SPTR: Glucosamine-6-phosphate isomerase; tmRNA as predicted by Rfam (RF00023), score 139.03; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; TIGRFAM: glucosamine-6-phosphate isomerase.
 
   
 0.606
Isop_1041
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR002035: IPR013126: IPR001023: IPR018181; KEGG: cac:CA_C0473 heat shock protein DnaK; PFAM: Heat shock protein 70; von Willebrand factor type A; SMART: von Willebrand factor type A; SPTR: DnaK protein (Heat shock protein), C-terminal region has VWA type A domain; PFAM: Hsp70 protein; von Willebrand factor type A domain.
  
  
 0.598
Isop_1039
Protein of unknown function DUF374; COGs: COG2121 conserved hypothetical protein; InterPro IPR007172; KEGG: psl:Psta_3561 protein of unknown function DUF374; PFAM: protein of unknown function DUF374; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF374).
       0.558
Isop_0492
COGs: COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase; InterPro IPR006148; KEGG: gym:GYMC10_1212 glucosamine-6-phosphate deaminase; PFAM: glucosamine/galactosamine-6-phosphate isomerase; SPTR: Glucosamine/galactosamine-6-phosphate isomerase; PFAM: Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.
 
   
 0.536
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
    0.530
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.511
Isop_3607
InterPro IPR000933; KEGG: cai:Caci_0886 alpha-L-fucosidase; SMART: glycoside hydrolase family 29 (alpha-L-fucosidase); SPTR: Alpha-L-fucosidase; PFAM: Alpha-L-fucosidase.
 
   
 0.457
Isop_3307
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; COGs: COG1446 Asparaginase; InterPro IPR006311: IPR017909: IPR000246; KEGG: srm:SRM_02869 asparaginase; PFAM: peptidase T2 asparaginase 2; PRIAM:N(4)-(beta-N-acetylglucosaminyl)-L-asparagina se; SPTR: Asparaginase; PFAM: Asparaginase; TIGRFAM: Tat (twin-arginine translocation) pathway signal sequence.
 
     0.449
Isop_1614
Na-Ca exchanger/integrin-beta4; InterPro IPR006118: IPR003644; KEGG: mpd:MCP_2796 hypothetical protein; PFAM: Na-Ca exchanger/integrin-beta4; SMART: Na-Ca exchanger/integrin-beta4; SPTR: Probable aggregation factor core protein MAFp3, isoform C; PFAM: Calx-beta domain.
 
    0.430
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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