Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_1059COGs: COG3597 Uncharacterized protein/domain associated with GTPase; KEGG: alv:Alvin_1745 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: GTPase of unknown function; Domain of unknown function (DUF697). (429 aa)    
Predicted Functional Partners:
Isop_1058
GTP-binding protein HSR1-related protein; COGs: COG0486 GTPase; InterPro IPR002917; KEGG: alv:Alvin_1744 GTP-binding protein HSR1-related protein; PFAM: GTP-binding protein HSR1-related; SPTR: GTP-binding protein HSR1-related protein; PFAM: GTPase of unknown function.
 
     0.921
Isop_2506
KEGG: plm:Plim_3939 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.694
Isop_1060
ABC-3 protein; COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001367: IPR001626; KEGG: psl:Psta_4677 ABC-3 protein; PFAM: ABC-3 protein; iron dependent repressor; SMART: iron dependent repressor; SPTR: ABC-3 protein; PFAM: ABC 3 transport family; Iron dependent repressor, metal binding and dimerisation domain.
       0.555
Isop_1061
ABC-3 protein; COGs: COG1108 ABC-type Mn2+/Zn2+ transport systems permease components; InterPro IPR001626; KEGG: psl:Psta_4676 ABC-3 protein; PFAM: ABC-3 protein; SPTR: ABC-3 protein; PFAM: ABC 3 transport family.
       0.555
Isop_2029
Protein of unknown function DUF820; InterPro IPR008538; KEGG: rrs:RoseRS_2740 hypothetical protein; PFAM: protein of unknown function DUF820; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF820).
  
     0.520
Isop_2989
Hypothetical protein; KEGG: hha:Hhal_1736 putative ABC transporter; SPTR: Putative ABC transporter.
  
     0.494
Isop_3138
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
     0.485
Isop_1062
ABC transporter related protein; COGs: COG1121 ABC-type Mn/Zn transport systems ATPase component; InterPro IPR003593: IPR003439: IPR017871; KEGG: psl:Psta_4675 ABC transporter related protein; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related protein; PFAM: ABC transporter.
       0.454
Isop_1063
Periplasmic solute binding protein; COGs: COG0803 ABC-type metal ion transport system periplasmic component/surface adhesin; InterPro IPR006311: IPR006127: IPR006128: IPR006129; KEGG: sth:STH1506 ABC transporter permease protein; PFAM: periplasmic solute binding protein; SPTR: ABC transporter permease protein; PFAM: Periplasmic solute binding protein family; Belongs to the bacterial solute-binding protein 9 family.
       0.454
Isop_0494
Protein of unknown function DUF820; InterPro IPR008538; KEGG: rca:Rcas_2194 hypothetical protein; PFAM: protein of unknown function DUF820; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF820).
  
     0.412
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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