STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
kynATryptophan 23-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (368 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
 0.804
trpB
Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
       0.773
Isop_1067
Hypothetical protein; KEGG: tro:trd_0686 transcriptional regulator; SPTR: Putative regulatory protein.
       0.773
Isop_3268
Maf protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
   0.704
Isop_1055
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
  
 
   0.693
Isop_1068
Hypothetical protein.
       0.453
Isop_1069
KEGG: fra:Francci3_2916 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF2029).
       0.453
Isop_0005
NUDIX hydrolase; COGs: COG1051 ADP-ribose pyrophosphatase; InterPro IPR020476: IPR020084: IPR000086; KEGG: ngr:NAEGRDRAFT_49855 hypothetical protein; PFAM: NUDIX hydrolase; SPTR: Hydrolase, NUDIX family protein; PFAM: NUDIX domain.
  
     0.431
Isop_2580
Peptidase S45 penicillin amidase; COGs: COG2366 Protein related to penicillin acylase; InterPro IPR002692: IPR014395; KEGG: ote:Oter_0831 penicillin amidase; PFAM: peptidase S45 penicillin amidase; SPTR: Penicillin amidase; PFAM: Penicillin amidase.
  
     0.408
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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