STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1074Phytanoyl-CoA dioxygenase; COGs: COG5285 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin; InterPro IPR008775; KEGG: psl:Psta_2684 phytanoyl-CoA dioxygenase; PFAM: Phytanoyl-CoA dioxygenase; SPTR: Syringomycin biosynthesis enzyme 2-like protein; PFAM: Phytanoyl-CoA dioxygenase (PhyH). (298 aa)    
Predicted Functional Partners:
Isop_1075
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR017909: IPR000683; KEGG: plm:Plim_0006 oxidoreductase domain protein; PFAM: oxidoreductase domain protein; SPTR: Oxidoreductase domain protein; PFAM: Oxidoreductase family, C-terminal alpha/beta domain; Oxidoreductase family, NAD-binding Rossmann fold.
  
    0.614
Isop_0676
COGs: COG3386 Gluconolactonase; InterPro IPR005511: IPR013658; KEGG: plm:Plim_3928 gluconolactonase; PFAM: SMP-30/Gluconolaconase/LRE-like region-containing protein; PRIAM: Gluconolactonase; SPTR: Gluconolactonase (Precursor); PFAM: SMP-30/Gluconolaconase/LRE-like region.
  
    0.497
Isop_1073
Peptidase S8 and S53 subtilisin kexin sedolisin; COGs: COG4935 Regulatory P domain of the subtilisin-like proprotein convertase and other protease; InterPro IPR000209: IPR002884; KEGG: mar:MAE_12430 hypothetical protein; PFAM: peptidase S8 and S53 subtilisin kexin sedolisin; Proprotein convertase P; SPTR: Putative uncharacterized protein; PFAM: Proprotein convertase P-domain; Subtilase family.
  
    0.478
Isop_1865
Xylose isomerase domain-containing protein TIM barrel; COGs: COG1082 Sugar phosphate isomerase/epimerase; InterPro IPR012307: IPR017909; KEGG: psl:Psta_2217 xylose isomerase domain protein TIM barrel; PFAM: Xylose isomerase domain-containing protein TIM barrel; SPTR: Probable IolI protein; PFAM: Xylose isomerase-like TIM barrel.
 
   
 0.469
Isop_2214
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
      
 0.434
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.428
Isop_2332
KEGG: psl:Psta_1770 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Neutral/alkaline non-lysosomal ceramidase.
  
     0.421
Isop_1076
parB-like partition protein; COGs: COG1475 transcriptional regulator protein; InterPro IPR003115: IPR004437: IPR001387; KEGG: rba:RB2296 chromosome partitioning protein ParB; PFAM: ParB domain protein nuclease; helix-turn-helix domain protein; SMART: ParB domain protein nuclease; SPTR: Probable chromosome partitioning protein parB; TIGRFAM: parB-like partition protein; PFAM: Helix-turn-helix; ParB-like nuclease domain; TIGRFAM: ParB-like partition proteins; Belongs to the ParB family.
     
 0.419
Isop_0292
Heme-binding protein; InterPro IPR009056: IPR013427; KEGG: plm:Plim_3308 heme-binding protein; SPTR: Putative uncharacterized protein; TIGRFAM: heme-binding protein; PFAM: Cytochrome c; TIGRFAM: putative heme-binding domain, Pirellula/Verrucomicrobium type.
  
     0.414
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.