STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Isop_1076parB-like partition protein; COGs: COG1475 transcriptional regulator protein; InterPro IPR003115: IPR004437: IPR001387; KEGG: rba:RB2296 chromosome partitioning protein ParB; PFAM: ParB domain protein nuclease; helix-turn-helix domain protein; SMART: ParB domain protein nuclease; SPTR: Probable chromosome partitioning protein parB; TIGRFAM: parB-like partition protein; PFAM: Helix-turn-helix; ParB-like nuclease domain; TIGRFAM: ParB-like partition proteins; Belongs to the ParB family. (303 aa)    
Predicted Functional Partners:
Isop_2378
Cobyrinic acid ac-diamide synthase; COGs: COG1192 ATPase involved in chromosome partitioning; KEGG: psl:Psta_0392 cobyrinic acid ac-diamide synthase; SPTR: Cobyrinic acid ac-diamide synthase; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
 
 
 0.938
Isop_1189
Cell division protein FtsK/SpoIIIE; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593: IPR002543: IPR018541; KEGG: psl:Psta_2807 cell divisionFtsK/SpoIIIE; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: AAA ATPase; SPTR: Cell divisionFtsK/SpoIIIE; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family.
  
   
 0.737
rsmG
Methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
  
 0.646
Isop_0986
KEGG: psl:Psta_0111 organic solvent tolerance protein OstA-like protein; SPTR: Organic solvent tolerance protein OstA-like protein.
    
 
 0.584
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
  
 0.559
Isop_1075
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR017909: IPR000683; KEGG: plm:Plim_0006 oxidoreductase domain protein; PFAM: oxidoreductase domain protein; SPTR: Oxidoreductase domain protein; PFAM: Oxidoreductase family, C-terminal alpha/beta domain; Oxidoreductase family, NAD-binding Rossmann fold.
  
    0.502
xerC-2
Integrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
  
  
 0.468
xerC
Tyrosine recombinase XerD subunit; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
  
  
 0.453
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.436
Isop_3433
Chromosomal replication initiator DnaA; COGs: COG0593 ATPase involved in DNA replication initiation; InterPro IPR013317: IPR013159; KEGG: cwo:Cwoe_0001 chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication initiator DnaA; Chromosomal replication initiator DnaA domain; SMART: Chromosomal replication initiator DnaA domain; SPTR: Chromosomal replication initiator protein dnaA; PFAM: domain; Bacterial dnaA protein.
 
  
 0.421
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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