STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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Isop_1104Ribonuclease, Rne/Rng family; COGs: COG1530 Ribonuclease G and E; InterPro IPR003029: IPR004659: IPR019307; KEGG: psl:Psta_2436 ribonuclease, Rne/Rng family; PFAM: RNA-binding protein AU-1/Ribonuclease E/G; RNA binding S1 domain protein; SPTR: Ribonuclease, Rne/Rng family; TIGRFAM: ribonuclease, Rne/Rng family; PFAM: Ribonuclease E/G family; S1 RNA binding domain; TIGRFAM: ribonuclease, Rne/Rng family. (1473 aa)    
Predicted Functional Partners:
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.837
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 
 0.789
Isop_1517
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterProIPR014021: IPR001650: IPR014014: IPR000629: IPR 014001: IPR011545; KEGG: psl:Psta_1620 DEAD/DEAH box helicase domain protein; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DEAD/DEAH box helicase domain protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
    
 
 0.749
Isop_1946
COGs: COG0349 Ribonuclease D; InterPro IPR002562: IPR002121: IPR006292; KEGG: plm:Plim_0672 ribonuclease D; PFAM: 3'-5' exonuclease; HRDC domain protein; PRIAM: Ribonuclease D; SMART: 3'-5' exonuclease; HRDC domain protein; SPTR: Ribonuclease D; TIGRFAM: ribonuclease D; PFAM: HRDC domain; 3'-5' exonuclease; TIGRFAM: ribonuclease D.
  
  
 0.673
rph
RNAse PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
  
 0.663
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
 
 0.651
Isop_1658
COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; InterPro IPR019734: IPR013026: IPR011260: IPR001440; KEGG: psl:Psta_3991 RNA polymerase alpha subunit domain protein; PFAM: RNA polymerase alpha subunit domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SPTR: RNA polymerase alpha subunit domain protein; PFAM: Tetratricopeptide repeat; Bacterial RNA polymerase, alpha chain C terminal domain.
 
  
 0.572
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.520
Isop_1106
Protein of unknown function DUF2344; COGs: COG5011 conserved hypothetical protein; InterPro IPR018768; KEGG: afw:Anae109_0737 radical SAM domain-containing protein; PFAM: Protein of unknown function DUF2344; SPTR: Radical SAM domain protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2344).
       0.516
Isop_1108
COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR000032: IPR005698; KEGG: gau:GAU_1482 phosphocarrier protein HPr; PFAM: phosphoryl transfer system HPr; SPTR: Phosphocarrier protein HPr; TIGRFAM: phosphocarrier, HPr family; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family.
       0.508
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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