Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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Isop_1108COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR000032: IPR005698; KEGG: gau:GAU_1482 phosphocarrier protein HPr; PFAM: phosphoryl transfer system HPr; SPTR: Phosphocarrier protein HPr; TIGRFAM: phosphocarrier, HPr family; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family. (121 aa)    
Predicted Functional Partners:
Isop_0677
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.996
Isop_1107
Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 
 0.993
Isop_1264
Hypothetical protein; KEGG: sus:Acid_2874 transmembrane prediction; SPTR: Putative uncharacterized protein.
   
 
 0.834
Isop_1106
Protein of unknown function DUF2344; COGs: COG5011 conserved hypothetical protein; InterPro IPR018768; KEGG: afw:Anae109_0737 radical SAM domain-containing protein; PFAM: Protein of unknown function DUF2344; SPTR: Radical SAM domain protein; PFAM: Uncharacterized protein conserved in bacteria (DUF2344).
       0.788
Isop_1109
PTS IIA-like nitrogen-regulatory protein PtsN; COGs: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); InterPro IPR002178; KEGG: plm:Plim_0361 phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; SPTR: Phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; PFAM: Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.
 
  
 0.776
Isop_1105
KEGG: lch:Lcho_2901 hypothetical protein; SPTR: Helicase.
       0.773
Isop_3613
Response regulator receiver modulated GAF sensor protein; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789: IPR003018; KEGG: rba:RB7461 sensor kinase; PFAM: response regulator receiver; GAF domain protein; SMART: response regulator receiver; GAF domain protein; SPTR: Probable sensor kinase; PFAM: Response regulator receiver domain; GAF domain.
    
 
 0.694
rpsG
SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
    0.620
Isop_1019
PfkB domain protein; COGs: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); InterPro IPR011611: IPR002173; KEGG: sth:STH1246 tagatose-6-phosphate kinase; PFAM: PfkB domain protein; SPTR: Tagatose-6-phosphate kinase; PFAM: pfkB family carbohydrate kinase; TIGRFAM: hexose kinase, 1-phosphofructokinase family.
 
  
 0.574
Isop_3628
COGs: COG0058 Glucan phosphorylase; InterPro IPR011834: IPR000811; KEGG: psl:Psta_1121 alpha-glucan phosphorylase; PFAM: glycosyl transferase family 35; PRIAM: Phosphorylase; SPTR: Alpha-glucan phosphorylase; TIGRFAM: alpha-glucan phosphorylase; PFAM: Carbohydrate phosphorylase; Protein of unknown function (DUF3417); TIGRFAM: alpha-glucan phosphorylases.
   
 
 0.559
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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