STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (347 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.996
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.957
Isop_1669
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004408: IPR004143; KEGG: hne:HNE_1759 biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase; SPTR: Biotin [acetyl-CoA-carboxylase] ligase; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
  
 
 0.919
Isop_2785
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143: IPR004408; KEGG: mxa:MXAN_4152 BirA bifunctional protein; PFAM: biotin/lipoate A/B protein ligase; SPTR: BirA bifunctional protein; TIGRFAM: biotin/acetyl-CoA-carboxylase ligase; PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
  
 
 0.919
Isop_1125
8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839: IPR001917; KEGG: gau:GAU_2840 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
 
  
 0.874
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
  
  
 0.689
Isop_1126
Beta-ketoacyl synthase; COGs: COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; InterPro IPR014030: IPR014031; KEGG: tro:trd_A0447 beta-ketoacyl-acyl-carrier-protein synthase II; PFAM: Beta-ketoacyl synthase; SPTR: Putative uncharacterized protein; PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
  
 0.627
Isop_1128
KEGG: mth:MTH1810 hypothetical protein.
       0.511
Isop_1129
KEGG: plm:Plim_3503 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.511
Isop_1425
ABC transporter related protein; COGs: COG1122 ABC-type cobalt transport system ATPase component; InterPro IPR003439: IPR003339: IPR017871: IPR003593; KEGG: tbi:Tbis_0515 cobalt ABC transporter ATPase subunit; PFAM: ABC transporter related; cobalt transport protein; SMART: AAA ATPase; SPTR: Cobalt ABC transporter, ATPase subunit; PFAM: ABC transporter; Cobalt transport protein.
  
  
 0.495
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.