STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1135Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (349 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.738
Isop_3417
COGs: COG0394 Protein-tyrosine-phosphatase; InterPro IPR006070: IPR017867: IPR000106; KEGG: plm:Plim_2592 protein-tyrosine phosphatase, low molecular weight; PFAM: Protein-tyrosine phosphatase, low molecular weight; SUA5/yciO/yrdC domain; SMART: Protein-tyrosine phosphatase, low molecular weight; SPTR: Protein-tyrosine phosphatase, low molecular weight; PFAM: Low molecular weight phosphotyrosine protein phosphatase; yrdC domain; Belongs to the SUA5 family.
 
     0.687
Isop_1136
DNA photolyase FAD-binding protein; COGs: COG0415 Deoxyribodipyrimidine photolyase; InterPro IPR005101; KEGG: rca:Rcas_4249 deoxyribodipyrimidine photolyase-like protein; PFAM: DNA photolyase FAD-binding; SPTR: Probable deoxyribodipyrimidine photolyase; PFAM: FAD binding domain of DNA photolyase.
       0.682
Isop_1137
COGs: COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase; InterPro IPR007357: IPR005101; KEGG: rrs:RoseRS_0009 deoxyribodipyrimidine photolyase-related protein; PFAM: deoxyribodipyrimidine photolyase-related protein; DNA photolyase FAD-binding; SPTR: Deoxyribodipyrimidine photolyase-related protein; PFAM: FAD binding domain of DNA photolyase; Deoxyribodipyrimidine photo-lyase-related protein.
       0.682
prmC
protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
 
  
 0.641
tsaD
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
  
 0.613
Isop_2331
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR001678; KEGG: shw:Sputw3181_2798 Fmu (Sun) domain-containing protein; PFAM: Fmu (Sun) domain protein; SPTR: NOL1/NOP2/sun family putative RNA methylase; PFAM: NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
    0.442
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.