STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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Experiments
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[Homology]
Score
Isop_12373-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)    
Predicted Functional Partners:
Isop_0450
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR014043: IPR004410; KEGG: psl:Psta_1725 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase.
 0.996
fabH
3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.
 
 
 0.976
Isop_2372
Enoyl-(acyl-carrier-protein) reductase (NADH); COGs: COG0623 Enoyl-(acyl-carrier-protein); InterPro IPR002347; KEGG: plm:Plim_3893 short-chain dehydrogenase/reductase SDR; SPTR: Enoyl-[acyl-carrier-protein] reductase (NADH); PFAM: short chain dehydrogenase.
 
 
 0.965
Isop_0451
3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
  0.956
Isop_3360
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198: IPR002347: IPR020904; KEGG: dfe:Dfer_4758 3-ketoacyl-(acyl-carrier-protein) reductase; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase.
  
  0.937
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
 
 
 0.910
Isop_0521
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; COGs: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; InterPro IPR013114; KEGG: plm:Plim_3124 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; SPTR: Probable hydroxymyristoyl-(Acyl carrier protein) dehydratase; PFAM: FabA-like domain.
 
 
 0.829
Isop_0858
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; COGs: COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase; InterPro IPR013114; KEGG: plm:Plim_3297 beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; SPTR: Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA/FabZ; PFAM: FabA-like domain.
 
 
 0.815
Isop_1354
COGs: COG0321 Lipoate-protein ligase B; InterPro IPR004143; KEGG: plm:Plim_3383 lipoate-protein ligase B-like protein; PFAM: biotin/lipoate A/B protein ligase; SPTR: Lipoate-protein ligase B; TIGRFAM: lipoate-protein ligase B.
    
 0.807
Isop_2529
COGs: COG0095 Lipoate-protein ligase A; InterPro IPR004143; KEGG: plm:Plim_2597 biotin/lipoate A/B protein ligase; PFAM: biotin/lipoate A/B protein ligase; SPTR: Biotin/lipoate A/B protein ligase; PFAM: Biotin/lipoate A/B protein ligase family.
     
 0.802
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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