STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1352COGs: COG0266 Formamidopyrimidine-DNA glycosylase; InterProIPR000214: IPR012319: IPR000191: IPR015886: IPR 015887; KEGG: slp:Slip_1694 formamidopyrimidine-DNA glycosylase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; PRIAM: DNA-(apurinic or apyrimidinic site) lyase; SPTR: Putative uncharacterized protein; TIGRFAM: formamidopyrimidine-DNA glycosylase; PFAM: Formamidopyrimidine-DNA glycosylase H2TH domain; Formamidopyrimidine-DNA glycosylase N-terminal domain; TIGRFAM: formamidopyrimidine-DNA glycosylase (fpg). (288 aa)    
Predicted Functional Partners:
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
  
  
 0.767
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.700
Isop_1928
Excinuclease ABC C subunit domain protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
  
  
 0.688
Isop_0698
DEAD/DEAH box helicase domain protein; COGs: COG1201 Lhr-like helicase; InterProIPR011545: IPR001650: IPR013701: IPR014001: IPR 014021: IPR017170; KEGG: tga:TGAM_0576 ATP-dependent helicase; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: ATP-dependent helicase, lhr-like protein (Lhr); PFAM: Helicase conserved C-terminal domain; DEAD/H associated; DEAD/DEAH box helicase.
  
  
 0.596
Isop_2841
DEAD/H associated domain protein; COGs: COG1201 Lhr-like helicase; InterProIPR014021: IPR001650: IPR014001: IPR003593: IPR 011545: IPR013701; KEGG: sth:STH886 ATP-dependent DNA helicase; PFAM: DEAD/H associated domain protein; DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; AAA ATPase; helicase domain protein; SPTR: ATP-dependent DNA helicase; PFAM: Helicase conserved C-terminal domain; DEAD/H associated; DEAD/DEAH box helicase.
  
  
 0.596
Isop_1410
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013: IPR002054: IPR003583: IPR003141; KEGG: tte:TTE2516 family X DNA polymerase IV; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; SPTR: PHP domain protein; PFAM: PHP domain.
     
 0.473
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.433
Isop_2214
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterProIPR000583: IPR006982: IPR002932: IPR002489: IPR 017932; KEGG: ttr:Tter_0474 glutamate synthase (ferredoxin); PFAM: ferredoxin-dependent glutamate synthase; glutamine amidotransferase class-II; glutamate synthase; glutamate synthase alpha subunit domain protein; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
      
 0.409
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.