STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Isop_1367RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (273 aa)    
Predicted Functional Partners:
Isop_2585
InterPro IPR007412; KEGG: psl:Psta_4010 anti-sigma-28 factor, FlgM; PFAM: Anti-sigma-28 factor FlgM family protein; SPTR: Anti-sigma-28 factor, FlgM; TIGRFAM: Anti-sigma-28 factor FlgM family protein; PFAM: Anti-sigma-28 factor, FlgM; TIGRFAM: flagellar biosynthesis anti-sigma factor FlgM.
  
 0.994
Isop_2636
Protein serine/threonine phosphatase; COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR010822: IPR003594: IPR001932; KEGG: cli:Clim_1832 putative PAS/PAC sensor protein; PFAM: Stage II sporulation protein E; ATP-binding region ATPase domain protein; SMART: protein phosphatase 2C domain protein; SPTR: Putative PAS/PAC sensor protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Stage II sporulation protein E (SpoIIE).
  
 
 0.915
Isop_1369
Type III secretion FHIPEP protein; COGs: COG1298 Flagellar biosynthesis pathway component FlhA; InterPro IPR001712; KEGG: plm:Plim_1138 flagellar biosynthesis protein FlhA; PFAM: type III secretion FHIPEP protein; SPTR: Flagella-associated protein; PFAM: FHIPEP family; TIGRFAM: flagellar biosynthesis protein FlhA.
 
  
 0.903
Isop_2319
Type III secretion system inner membrane P protein; COGs: COG1338 Flagellar biosynthesis pathway component FliP; InterPro IPR005838; KEGG: adg:Adeg_2033 flagellar biosynthetic protein FliP; PFAM: type III secretion system inner membrane P protein; SPTR: Flagellar biosynthetic protein FliP; PFAM: FliP family.
 
  
 0.882
Isop_1841
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207: IPR004105: IPR003594: IPR002545: IPR 001789: IPR004358: IPR005467; KEGG: aeh:Mlg_0359 CheA signal transduction histidine kinases; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; CheW domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein; SPTR: CheA signal transduction histidine kin [...]
 
  
 0.876
Isop_3147
COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789: IPR003594; KEGG: sus:Acid_7798 response regulator receiver protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; SMART: response regulator receiver; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.876
Isop_3690
CheA signal transduction histidine kinase; COGs: COG0643 Chemotaxis protein histidine kinase and related kinase; InterProIPR008207: IPR003594: IPR002545: IPR001789: IPR 005467: IPR004105: IPR004358; KEGG: aeh:Mlg_0359 CheA signal transduction histidine kinases; PFAM: response regulator receiver; CheW domain protein; ATP-binding region ATPase domain protein; Hpt domain protein; Signal transducing histidine kinase homodimeric; SMART: response regulator receiver; ATP-binding region ATPase domain protein; Hpt domain protein; CheW domain protein; SPTR: CheA signal transduction histidine kin [...]
 
  
 0.861
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
 
 
 
 0.856
Isop_1658
COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; InterPro IPR019734: IPR013026: IPR011260: IPR001440; KEGG: psl:Psta_3991 RNA polymerase alpha subunit domain protein; PFAM: RNA polymerase alpha subunit domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SPTR: RNA polymerase alpha subunit domain protein; PFAM: Tetratricopeptide repeat; Bacterial RNA polymerase, alpha chain C terminal domain.
 
 
 
 0.830
rpoC
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.821
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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