STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-expression
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[Homology]
Score
Isop_1375thiamineS protein; InterPro IPR003749; KEGG: tfu:Tfu_2369 hypothetical protein; PFAM: thiamineS protein; SPTR: Putative uncharacterized protein; manually curated; PFAM: ThiS family. (90 aa)    
Predicted Functional Partners:
Isop_1376
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: sti:Sthe_0801 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: Molybdopterin biosynthesis protein MoeB; PFAM: MoeZ/MoeB domain; ThiF family.
  
 0.978
Isop_1342
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594; KEGG: psl:Psta_4146 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: UBA/THIF-type NAD/FAD binding protein; PFAM: ThiF family.
  
 0.959
Isop_3005
COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: plm:Plim_0864 molybdopterin biosynthesis MoaE protein; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Molybdopterin converting factor (Subunit 2); PFAM: MoaE protein.
  
 
 0.929
Isop_2632
Molybdopterin converting factor, subunit 1; InterPro IPR003749: IPR010034; KEGG: psl:Psta_2343 thiamineS protein; PFAM: thiamineS protein; SPTR: ThiamineS protein; TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: ThiS family; TIGRFAM: molybdopterin converting factor, subunit 1, non-archaeal.
  
  
  0.912
Isop_1374
COGs: COG0498 Threonine synthase; InterPro IPR004450: IPR001926; KEGG: tye:THEYE_A1678 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase.
 
     0.850
moaC
GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
  
 0.754
Isop_2295
Mov34/MPN/PAD-1 family protein; COGs: COG1310 metal-dependent protease of the PAD1/JAB1 superfamily; InterPro IPR000555; KEGG: tjr:TherJR_2271 Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; SPTR: Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1 family.
 
  
 0.733
Isop_2293
COGs: COG0031 Cysteine synthase; InterPro IPR005856: IPR005859: IPR001926; KEGG: psl:Psta_1771 cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase A; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases.
  
 
 0.639
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
  
 0.623
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
   
 0.567
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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