STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Isop_1376UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594: IPR007901; KEGG: sti:Sthe_0801 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: Molybdopterin biosynthesis protein MoeB; PFAM: MoeZ/MoeB domain; ThiF family. (361 aa)    
Predicted Functional Partners:
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.990
Isop_1375
thiamineS protein; InterPro IPR003749; KEGG: tfu:Tfu_2369 hypothetical protein; PFAM: thiamineS protein; SPTR: Putative uncharacterized protein; manually curated; PFAM: ThiS family.
  
 0.978
Isop_2632
Molybdopterin converting factor, subunit 1; InterPro IPR003749: IPR010034; KEGG: psl:Psta_2343 thiamineS protein; PFAM: thiamineS protein; SPTR: ThiamineS protein; TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: ThiS family; TIGRFAM: molybdopterin converting factor, subunit 1, non-archaeal.
 
 0.974
Isop_0815
Cysteine desulfurase IscS; COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR000192: IPR016454; KEGG: cre:CHLREDRAFT_191269 cysteine desulfurase; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Cysteine desulfurase; PFAM: Aminotransferase class-V.
   
 0.945
Isop_2132
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR016454: IPR000192; KEGG: rmr:Rmar_1215 aminotransferase class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Aminotransferase class V; PFAM: Aminotransferase class-V.
   
 0.945
Isop_1342
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594; KEGG: psl:Psta_4146 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; SPTR: UBA/THIF-type NAD/FAD binding protein; PFAM: ThiF family.
  
  
 
0.928
Isop_3005
COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: plm:Plim_0864 molybdopterin biosynthesis MoaE protein; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Molybdopterin converting factor (Subunit 2); PFAM: MoaE protein.
 
 0.915
Isop_1341
Ubiquitin-conjugating protein E2; InterPro IPR000608; KEGG: psl:Psta_4148 ubiquitin-conjugating protein E2; SPTR: Ubiquitin-conjugating protein E2; PFAM: Ubiquitin-conjugating enzyme.
   
 0.815
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.759
Isop_1377
Aminotransferase class V; COGs: COG0520 Selenocysteine lyase; InterPro IPR000192; KEGG: sti:Sthe_0800 cysteine desulfurase family protein; PFAM: aminotransferase class V; SPTR: Similar to selenocysteine lyase; PFAM: Aminotransferase class-V; TIGRFAM: cysteine desulfurase family protein.
 
  
 0.703
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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