Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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Isop_1457Glutamate--cysteine ligase; COGs: COG3572 Gamma-glutamylcysteine synthetase; InterPro IPR006336; KEGG: nml:Namu_1082 glutamate/cysteine ligase family protein; PFAM: glutamate--cysteine ligase GCS2; PRIAM: Glutamate--cysteine ligase; SPTR: Glutamate/cysteine ligase family protein; PFAM: Glutamate-cysteine ligase family 2(GCS2); TIGRFAM: glutamate--cysteine ligase, plant type. (472 aa)    
Predicted Functional Partners:
gshB
COGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR011761: IPR006284: IPR004215: IPR004218; KEGG: scl:sce7568 glutathione synthetase; PFAM: glutathione synthetase ATP-binding; glutathione synthetase domain protein; PRIAM: Glutathione synthase; SPTR: Glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain; TIGRFAM: glutathione synthetase, prokaryotic; Belongs to the prokaryotic GSH synthase family.
 
  
 0.929
Isop_0306
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: gau:GAU_2335 gamma-glutamyltranspeptidase precursor; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
  
  
  0.914
Isop_0121
Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
    
  0.900
Isop_1176
Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: ppp:PHYPADRAFT_141539 hypothetical protein; PFAM: aminotransferase class IV; SPTR: Putative branched chain amino acid aminotransferase; PFAM: Aminotransferase class IV.
     
  0.900
Isop_1222
COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: mca:MCA0477 allophanate hydrolase, subunit 2; PFAM: Allophanate hydrolase subunit 2; SMART: Allophanate hydrolase subunit 2; SPTR: Allophanate hydrolase, subunit 2; PFAM: Allophanate hydrolase subunit 2.
     
  0.900
Isop_1379
COGs: COG0308 Aminopeptidase N; InterPro IPR014782; KEGG: mxa:MXAN_0644 M1 family peptidase; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: Peptidase, M1 (Aminopeptidase N) family; PFAM: Peptidase family M1.
     
  0.900
Isop_2261
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: aba:Acid345_3078 gamma-glutamyltransferase 2; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
     
  0.900
ilvE
Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
pepA
Peptidase M17 leucyl aminopeptidase domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
     
  0.900
Isop_0123
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR002872: IPR015590; KEGG: psl:Psta_0870 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; SPTR: 1-pyrroline-5 carboxylate dehydrogenase; PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Belongs to the aldehyde dehydrogenase family.
   
 
  0.812
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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