Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
gshBCOGs: COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); InterPro IPR011761: IPR006284: IPR004215: IPR004218; KEGG: scl:sce7568 glutathione synthetase; PFAM: glutathione synthetase ATP-binding; glutathione synthetase domain protein; PRIAM: Glutathione synthase; SPTR: Glutathione synthetase; TIGRFAM: glutathione synthetase; PFAM: Prokaryotic glutathione synthetase, N-terminal domain; Prokaryotic glutathione synthetase, ATP-grasp domain; TIGRFAM: glutathione synthetase, prokaryotic; Belongs to the prokaryotic GSH synthase family. (321 aa)    
Predicted Functional Partners:
Isop_1457
Glutamate--cysteine ligase; COGs: COG3572 Gamma-glutamylcysteine synthetase; InterPro IPR006336; KEGG: nml:Namu_1082 glutamate/cysteine ligase family protein; PFAM: glutamate--cysteine ligase GCS2; PRIAM: Glutamate--cysteine ligase; SPTR: Glutamate/cysteine ligase family protein; PFAM: Glutamate-cysteine ligase family 2(GCS2); TIGRFAM: glutamate--cysteine ligase, plant type.
 
  
 0.929
Isop_0306
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: gau:GAU_2335 gamma-glutamyltranspeptidase precursor; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltransferase; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
  
  
 0.920
Isop_1001
InterPro IPR001129: IPR001446; KEGG: gvi:glr3057 glutathione S-transferase; PFAM: membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG); SPTR: Glr3057 protein; PFAM: MAPEG family.
 
  
  0.916
Isop_0121
Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
    
 0.913
pepA
Peptidase M17 leucyl aminopeptidase domain protein; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
   
 
 0.913
Isop_2902
Peroxiredoxin; COGs: COG0386 Glutathione peroxidase; InterPro IPR000889; KEGG: sus:Acid_7250 glutathione peroxidase; PFAM: glutathione peroxidase; PRIAM: Peroxiredoxin; SPTR: Glutathione peroxidase; PFAM: Glutathione peroxidase; Belongs to the glutathione peroxidase family.
     
 0.912
Isop_2261
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101; KEGG: aba:Acid345_3078 gamma-glutamyltransferase 2; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltransferase 2. Threonine peptidase. MEROPS family T03; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
     
 0.907
Isop_1379
COGs: COG0308 Aminopeptidase N; InterPro IPR014782; KEGG: mxa:MXAN_0644 M1 family peptidase; PFAM: Peptidase M1 membrane alanine aminopeptidase; SPTR: Peptidase, M1 (Aminopeptidase N) family; PFAM: Peptidase family M1.
     
 0.903
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.811
rplW
LSU ribosomal protein L23P; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.
  
 
   0.609
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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