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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Isop_1478Helicase c2; COGs: COG1199 Rad3-related DNA helicase; InterPro IPR014013: IPR014001: IPR006554: IPR006555; KEGG: plm:Plim_0188 helicase C2; SMART: helicase c2; Helicase-like, DEXD box c2 type; DEAD-like helicase; SPTR: Helicase c2; PFAM: Type III restriction enzyme, res subunit. (693 aa)    
Predicted Functional Partners:
Isop_1922
COGs: COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains; InterProIPR020046: IPR020047: IPR001098: IPR002421: IPR 008918: IPR002298: IPR018320: IPR019760; KEGG: plm:Plim_3011 DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: DNA-directed DNA polymerase; 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2; SPTR: DNA polymerase I; TIGRFAM: DNA polymerase I; PFAM: 5'-3' exonuclease, C-terminal SAM fold; 5'-3' exonuclease, N-terminal resolvase-like domain; DNA polym [...]
   
 0.910
Isop_1828
KEGG: sti:Sthe_2169 hypothetical protein; SPTR: Putative uncharacterized protein.
    
 0.902
Isop_2145
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 0.865
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.816
rpoZ
DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
  0.804
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
  0.755
Isop_1830
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterProIPR006935: IPR001650: IPR014001: IPR001161: IPR 014021; KEGG: mta:Moth_1918 DEAD/DEAH box helicase-like; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DEAD/DEAH box helicase-like; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit.
   
 0.741
Isop_2393
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterPro IPR014001: IPR001650: IPR006935: IPR014021; KEGG: scl:sce6811 DNA repair protein; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: DNA repair protein; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit.
   
 0.741
Isop_2443
Type III restriction protein res subunit; COGs: COG1061 DNA or RNA helicase of superfamily II; InterProIPR014021: IPR001650: IPR006935: IPR018886: IPR 014001; KEGG: mag:amb0356 superfamily II DNA/RNA helicase; PFAM: type III restriction protein res subunit; helicase domain protein; Uncharacterised protein family UPF0547; SMART: helicase domain protein; DEAD-like helicase; SPTR: Helicase domain protein; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit; Uncharacterised protein family UPF0547.
   
 0.741
Isop_1658
COGs: COG0202 DNA-directed RNA polymerase alpha subunit/40 kD subunit; InterPro IPR019734: IPR013026: IPR011260: IPR001440; KEGG: psl:Psta_3991 RNA polymerase alpha subunit domain protein; PFAM: RNA polymerase alpha subunit domain protein; Tetratricopeptide TPR_1 repeat-containing protein; SPTR: RNA polymerase alpha subunit domain protein; PFAM: Tetratricopeptide repeat; Bacterial RNA polymerase, alpha chain C terminal domain.
   
 0.726
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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