Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene co-occurrence
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Isop_1527COGs: COG4799 Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta); InterPro IPR011762: IPR011763: IPR000022; KEGG: psl:Psta_0088 propionyl-CoA carboxylase; PFAM: carboxyl transferase; PRIAM: Methylcrotonoyl-CoA carboxylase; SPTR: Propionyl-CoA carboxylase; PFAM: Carboxyl transferase domain. (554 aa)    
Predicted Functional Partners:
Isop_1586
Biotin/lipoyl attachment domain-containing protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR000089; KEGG: cag:Cagg_0997 biotin/lipoyl attachment domain-containing protein; PFAM: biotin/lipoyl attachment domain-containing protein; SPTR: Biotin/lipoyl attachment domain-containing protein; PFAM: Biotin-requiring enzyme.
 
 0.938
Isop_2168
Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 0.909
Isop_1528
Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0369 Sulfite reductase alpha subunit (flavoprotein); InterProIPR017927: IPR001709: IPR012146: IPR008333: IPR 001433; KEGG: gvi:gvip312 ferredoxin--NADP+ reductase; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: Ferredoxin--NADP+ reductase; manually curated; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain.
       0.618
Isop_3707
COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR006089: IPR006092: IPR006091: IPR006090; KEGG: psl:Psta_3650 acyl-CoA dehydrogenase domain protein; PFAM: acyl-CoA dehydrogenase domain-containing protein; SPTR: Acyl-CoA dehydrogenase domain protein; PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain.
 
 
 0.617
Isop_1529
6-phosphogluconate dehydrogenase NAD-binding protein; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR006115; KEGG: hoh:Hoch_3369 6-phosphogluconate dehydrogenase NAD-binding protein; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; SPTR: 3-hydroxyisobutyrate dehydrogenase; PFAM: NAD binding domain of 6-phosphogluconate dehydrogenase.
 
    0.611
Isop_1449
COGs: COG1960 Acyl-CoA dehydrogenase; InterPro IPR006092: IPR006091: IPR006090; KEGG: gur:Gura_2352 acyl-CoA dehydrogenase domain-containing protein; PFAM: acyl-CoA dehydrogenase domain-containing protein; SPTR: Acyl-CoA dehydrogenase domain protein; PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain.
 
 
 0.605
Isop_2003
KR domain protein; COGs: COG3321 Polyketide synthase modules and related protein; InterProIPR014031: IPR014043: IPR006163: IPR013968: IPR 009081; KEGG: glo:Glov_2267 polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: KR domain protein; Beta-ketoacyl synthase; Acyl transferase; phosphopantetheine-binding; SPTR: Polyketide-type polyunsaturated fatty acid synthase PfaA; PFAM: Acyl transferase domain; Phosphopantetheine attachment site; KR domain; Beta-ketoacyl synthase, C-terminal domain; TIGRFAM: acyl carrier protein.
  
 
 0.556
Isop_1589
methylmalonyl-CoA epimerase; InterPro IPR017515: IPR004360; KEGG: glo:Glov_3258 methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; SPTR: Methylmalonyl-CoA epimerase; TIGRFAM: methylmalonyl-CoA epimerase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: methylmalonyl-CoA epimerase.
  
  
 0.551
Isop_2488
Protein of unknown function DUF1446; InterPro IPR010839; KEGG: sus:Acid_3874 hypothetical protein; PFAM: protein of unknown function DUF1446; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF1446).
  
  
 0.548
Isop_0610
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.529
Your Current Organism:
Isosphaera pallida
NCBI taxonomy Id: 575540
Other names: I. pallida ATCC 43644, Isosphaera pallida ATCC 43644, Isosphaera pallida DSM 9630, Isosphaera pallida IS1B, Isosphaera pallida str. ATCC 43644, Isosphaera pallida strain ATCC 43644
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